Results 121 to 130 of about 601,448 (407)

Superiority of Transcriptional Profiling Over Procalcitonin for Distinguishing Bacterial From Viral Lower Respiratory Tract Infections in Hospitalized Adults

Journal of Infectious Diseases, 2015
Background. Distinguishing between bacterial and viral lower respiratory tract infection (LRTI) remains challenging. Transcriptional profiling is a promising tool for improving diagnosis in LRTI. Methods. We performed whole blood transcriptional analysis
N. Suárez, Eleonora Bunsow, A. Falsey, E. Walsh, A. Mejías, O. Ramilo   +5 more
semanticscholar   +1 more source

Targeting PTBP3‐Mediated Alternative Splicing of COX11 Induces Cuproptosis for Inhibiting Gastric Cancer Peritoneal Metastasis

Advanced Science, EarlyView.
The splicing factor PTBP3 promotes COX11 exon skipping, allowing gastric cancer organoids to evade cuproptosis. Antisense oligonucleotide drugs targeting PTBP3‐mediated COX11 alternative splicing, in combination with copper ionophores, promote cuproptosis in organoids, thereby providing a therapeutic approach for gastric cancer peritoneal metastasis ...
Yajing Zhou, Chao Dong, Xiaochun Shen, Pengbo Wang, Tao Chen, Weikang Li, Xiaotong Sun, Peiyuan Li, Chengxiang Xu, Kaipeng Duan, Dongbao Li, Jin Zhou   +11 more
wiley   +1 more source

Practice patterns for lower respiratory tract infections in hospital patients with particular focus on bacteriological examinations and injection antibiotics use

International Journal of General Medicine, 2013
Mikio Wada,1 Takeo Nakayama,2 Tatsuro Ishizaki,3 Toshihiko Satoh,4 Shunya Ikeda51General Internal Medicine, Fukuchiyama City Hospital, Fukuchiyama, Kyoto, Japan; 2Department of Health Informatics, Kyoto University School of Public Health, Kyoto, Japan ...
Wada M, Nakayama T, Ishizaki T, Satoh T, Ikeda S   +4 more
doaj  

Viral Lower Respiratory Tract Infections

, 2017
Lower respiratory tract infections in children are often viral in origin. Unfortunately in this time of significant antimicrobial resistance of infectious organisms, especially bacteria, there is still a tendency for clinicians to manage a child who coughs with antibiotics.
Heather J. Zar, Shabir A. Madhi, Debbie A White, Robin J. Green   +3 more
openaire   +2 more sources

Risk of infections in bronchiectasis during disease-modifying treatment and biologics for rheumatic diseases [PDF]

, 2011
Background Bronchiectasis is frequently associated (up to 30%) with chronic inflammatory rheumatic diseases and leads to lower respiratory tract infections.
AB Chang, AE O'Donnell, AF Barker, B Amor, B Cortet, B Karadag, C Salliot, EC Dasenbrook, EM Tan, F Tubach, FC Arnett, Guillaume Geri, IS Patel, J Askling, J Listing, JP Leombruno, KG Saag, L Lieberman-Maran, Laure Gossec, M Remy-Jardin, MA Martinez-Garcia, Maxime Dougados, MC Hochberg, MF Doran, MF Doran, MP Murray, N Tanaka, Nuria Del Castillo Pinol, O Bouyahia, P Emery, P King, PT King, RW Geckler, Sabrina Dadoun, SB Cohen, SD Sagel, SH Zrour, Simon Paternotte, T Bongartz, Tach Bui, WG Dixon, WU Hassan   +41 more
core   +3 more sources

The Lung Microbiome Modulates Pain‐Like Behavior Via the Lung–Brain Axis in a Nitroglycerin‐Induced Chronic Migraine Mouse Model

Advanced Science, EarlyView.
Intratracheal neomycin alters pulmonary microbiota, activating the vagus nerve via lung brain‐derived neurotrophic factor/tropomyosin receptor kinase B (BDNF/TrkB) pathway, further projecting to nucleus of solitary tract (NTS), then dorsal raphe nucleus (DRN), where activated serotoninergic neurons increase brain serotonin, alleviating migraine.
Biying Liu, Chengya Huang, Xin Li, Haonan Yu, Yuefeng Xia, Kun Liu, Xingji You, Jingxiang Wu   +7 more
wiley   +1 more source

Evaluation of an automated analytical system for rapid screening of lower respiratory tract infections

Microbiologia Medica, 2012
Respiratory tract infections are relevant causes of morbidity and mortality. It has been demonstrated that an appropriate initial antimicrobial regimen, or its early modification based on microbiological results, leads to a higher survival rate ...
Shamanta Grosso, Graziano Bruschetta, Laura Favero, Marisa Gobbo, Paola Zigante, Alessandro Camporese   +5 more
doaj   +1 more source

Single‐Cell Sequencing‐Guided Annotation of Rare Tumor Cells for Deep Learning‐Based Cytopathologic Diagnosis of Early Lung Cancer

Advanced Science, EarlyView.
This study presents an innovative method to generate high‐quality, objectively annotated cytology datasets without relying on expert involvement. Large‐scale single‐cell DNA sequencing is used as an objective ground truth of cell annotation for generating an accurate, unbiased dataset of exfoliated tumor cells from bronchoalveolar lavage cytology ...
Yichun Zhao, Ruoran Qiu, Zhuo Wang, Yunyun Li, Xu Yang, Yanlin Li, Xiaohan Shen, Yun Liu, Ziqiang Chen, Qihan You, Qihui Shi   +10 more
wiley   +1 more source

Analysis of the results of 13 combined pathogen detection in 3966 hospitalised children with acute lower respiratory tract infection

Scientific Reports
Early and accurate identification of infectious pathogens can facilitate appropriate drug use and reduce both the duration and financial burden associated with hospital stays.
Jiming Li, Huifen Zhang, Qunshan Xu, Zhimeng Huang   +3 more
doaj   +1 more source

Guidelines for the management of adult lower respiratory tract infections ‐ Full version

Clinical Microbiology and Infection, 2011
This document is an update of Guidelines published in 2005 and now includes scientific publications through to May 2010. It provides evidence-based recommendations for the most common management questions occurring in routine clinical practice in the ...
M. Woodhead, F. Blasi, S. Ewig, J. Garau, G. Huchon, M. Ieven, Å. Örtqvist, T. Schaberg, A. Torres, G. V. D. Heijden, R. Read, T. Verheij   +11 more
semanticscholar   +1 more source