Results 191 to 200 of about 259,922 (311)

Chemical Profiling, In Silico and In Vitro Studies to Identify Potential CDK2 and mTOR Inhibitor From Selaginella inaequalifolia (Hook. & Grev.) Spring Ethanolic Extracts

Chemistry &Biodiversity, EarlyView.
ABSTRACT The current study is aimed to reveal the phytoprofile of Selaginella inaequalifolia (Hook. & Grev.) Spring using GC–MS and predict the drug properties, toxicity, biological properties of S. inaequalifolia ethanolic extracts (SiEE) using in silico methods and in vitro toxicity assays, namely, MTT and BSLB assay.
Johnson Marimuthu Alias Antonysamy, Sivaraman Arumugam, Robin Charles Antony Arulraj, Anne Wincy Jacob Thomas, Henrique D. M. Coutinho   +4 more
wiley   +1 more source

Editorial for Special Issue "Antimicrobial Treatment of Lower Respiratory Tract Infections". [PDF]

Antibiotics (Basel)
Moschopoulos CD, Kotanidou A, Tsiodras S, Fragkou PC.   +3 more
europepmc   +1 more source

Endovascular Stenting for Pulmonary Vein Stenosis Following Atrial Fibrillation Ablation: From Diagnosis to Intervention

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Pulmonary vein stenosis (PVS) is an uncommon but serious complication of atrial fibrillation (AF) ablation, often misinterpreted as primary pulmonary disease. Timely identification is essential to prevent irreversible injury and to guide appropriate referral for interventional management. Case Presentations Through the discussion of
Cristina Aurigemma, Marco Busco, Francesco Bianchini, Gabriella Locorotondo, Francesca Graziani, Annalisa Pasquini, Enrico Romagnoli, Mattia Lunardi, Lazzaro Paraggio, Francesco Varone, Andrea Smargiassi, Bruno Iovene, Riccardo Marano, Carlo Trani, Francesco Burzotta   +14 more
wiley   +1 more source

Lung function trajectories in children with pulmonary TB and non-TB lower respiratory tract infections. [PDF]

IJTLD Open
Courtney IJ, Palmer M, Swanepoel R, Lombard CJ, van Niekerk M, Dunbar R, McCollum ED, Schaaf HS, Gie A, Goussard P, Hesseling AC, Jongen VW, van der Zalm MM.   +12 more
europepmc   +1 more source

Verekitug, a Novel Antibody Antagonist to the TSLP Receptor in Adults with Asthma: A 32‐Week Randomized Phase 1b Multiple Ascending‐Dose Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Verekitug, a novel, high‐affinity, fully human monoclonal antibody targeting thymic stromal lymphopoietin receptor (TSLPR), is in development as a potential treatment for severe asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), and chronic obstructive pulmonary disease (COPD).
Dave Singh, Chaim M. Brickman, Peter Lloyd, Ashish Kalra, Subhabrata Biswas, Arkadeep Sinha, Alex Mulvanny, Sumathi Sivapalasingam, Oren M. Becker, Aaron Deykin   +9 more
wiley   +1 more source

Ventilator-associated lower respiratory tract infections and bacteremia in medical and surgical critical care patients colonized by multidrug-resistant bacteria. [PDF]

BMC Infect Dis
Torres I, Ferrer J, Colomina J, Clari MÁ, Olea B, Giménez E, Albert E, Sánchez-Jordán P, Aguilar G, Carbonell N, Navarro D.   +10 more
europepmc   +1 more source

Population Pharmacokinetics of Clesrovimab in Preterm and Full‐Term Infants

Clinical Pharmacology &Therapeutics, EarlyView.
Clesrovimab is a half‐life extended monoclonal antibody targeting the respiratory syncytial virus fusion protein. Three studies (phase Ib/IIa [MK‐1654‐002], phase IIb/III [CLEVER], and phase III [SMART]) were conducted to evaluate the efficacy, safety, and pharmacokinetics (PK) of clesrovimab in infants.
Ziheng Hu, Farina Hellmann, Xiaowei Zang, Nele Plock, Keyur Parmar, Radha A. Railkar, S. Y. Amy Cheung, Brian M. Maas, Ferdous Gheyas   +8 more
wiley   +1 more source

Nosocomial lower respiratory tract infections in patients with immunosuppression: a cohort study. [PDF]

Ann Intensive Care
Reyes LF, Sanabria-Herrera N, Nseir S, Ranzani OT, Povoa P, Diaz E, Schultz MJ, Rodríguez A, Serrano-Mayorga CC, De Pascale G, Navalesi P, Skoczynski S, Esperatti M, Coelho LM, Cortegiani A, Aliberti S, Caricato A, Salzer HJF, Ceccato A, Civljak R, Soave PM, Luyt CE, Ekren PK, Rios F, Masclans JR, Marin J, Iglesias-Moles S, Nava S, Chiumello D, Bos LDJ, Artigas A, Froes F, Grimaldi D, Panigada M, Taccone FS, Antonelli M, Torres A, Martin-Loeches I, European Network for ICU-Related Respiratory Infections (ENIRRIs) European Respiratory Society-Clinical Research Collaboration Investigators.   +38 more
europepmc   +1 more source

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source

Metagenomic Next-Generation Sequencing of Bronchoalveolar Lavage Fluids Improves Pathogen Detection and Antimicrobial Stewardship in Lower Respiratory Tract Infections: A Retrospective Study. [PDF]

Infect Drug Resist
Ma X, Zhang Q, Ji X, Xia Y, Cao J, Xu X.
europepmc   +1 more source