Results 71 to 80 of about 6,658,435 (302)

Antibiotic prescription rate for upper respiratory tract infections and risks for unnecessary prescription in Croatia [Stopa propisivanja antibiotika za infekcije gornjeg dišnog trakta i rizici za nepotrebno propisivanje antibiotika u Hrvatskoj] [PDF]

, 2013
Overprescribing of antibiotics in primary care has been recognized as public health problem. We investigated visits prescription rate of antibiotics to patients with upper respiratory tract infections (URTI) and unnecessary prescription for ...
Kern, Josipa, Botica, Iva, Stamenić, Valerija, Stojanović Špehar, Stanislava, Tambić Andrašević, Arjana, Vrca Botica, Marija   +5 more
core   +1 more source

Parental engagement in research on paediatric lower respiratory tract infections in Indonesia

BMC Pediatrics
Background Lower respiratory tract infections (LRTIs) in children are a major concern in Indonesia as it is the leading cause of morbidity and mortality. Therefore, research on LRTIs is crucial to improve children’s health.
Vincentia Rizke Ciptaningtyas, Tanjung Ayu Sumekar, Quirijn de Mast, Marinus Isaäk de Jonge, Ani Margawati   +4 more
doaj   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

ETIOLOGY, CLINICAL MANIFESTATIONS, AND AGE CHARACTERISTICS OF MIXED VIRAL RESPIRATORY INFECTIONS WITHIN 2024-2025

Problems of Infectious and Parasitic Diseases
Introduction: This study aims to investigate mixed viral respiratory infections, examining their causes, age patterns, and the involvement of co-pathogens in the lower respiratory tract infections (LRTIs).
Dyana Pavlova, Ivelina Trifonova, Neli Korsun, Petar Velikov, Ivan Ivanov, Daniel Ivanov, Trifon Valkov, Iva Christova   +7 more
doaj   +1 more source

Influence of age, severity of infection, and co-infection on the duration of respiratory syncytial virus (RSV) shedding [PDF]

, 2015
RSV is the most important viral cause of pneumonia and bronchiolitis in children worldwide and has been associated with significant disease burden. With the renewed interest in RSV vaccines, we provide realistic estimates on duration, and influencing ...
Agoti, Charles N., Munywoki, Patrick Kiio, Koech, Dorothy C., Kipkoech, J., Medley, Graham, Cane, Patricia, Nokes, D. James, Kibirige, N.   +7 more
core   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Understanding parental consent and trust in paediatric LRTI research: insights from a qualitative study in Indonesia

BMC Public Health
Background Scientific research is essential to reduce the burden of paediatric lower respiratory tract infections (LRTI), one of the leading causes of death in children under five years of age in Indonesia.
Vincentia Rizke Ciptaningtyas, Tanjung Ayu Sumekar, Lathifa Putry Fauzia, Quirijn de Mast, Marinus Isaäk de Jonge, Ani Margawati   +5 more
doaj   +1 more source

Generation of Nasal Cell‐Derived Human Alveolar Organoids and Organoid‐Macrophage Assembloids for in Vitro Lung Modeling

Advanced Science, EarlyView.
This study demonstrates the generation of human alveolar organoids from nasal cells, which, when co‐cultured with monocyte‐derived macrophages, promotes maturation of both components and forms alveolar assembloids resembling native alveoli. These alveolar organoids and assembloids offer accessible, physiologically relevant in vitro systems for ...
Man Chun Chiu, Shuxin Zhang, Cun Li, Yifei Yu, Zhixin Wan, Jingjing Huang, Wei Xue, Ying Zhou, Xiaoxin Zhu, Qiaoshuai Lan, Jiali Wu, Zijun Zhao, Yuhong Liu, Xinjie Meng, Lin Huang, Hin Chu, Honglin Chen, Kelvin Kai‐Wang To, Kwok Yung Yuen, Jie Zhou   +19 more
wiley   +1 more source

Practice patterns for lower respiratory tract infections in hospital patients with particular focus on bacteriological examinations and injection antibiotics use

International Journal of General Medicine, 2013
Mikio Wada,1 Takeo Nakayama,2 Tatsuro Ishizaki,3 Toshihiko Satoh,4 Shunya Ikeda51General Internal Medicine, Fukuchiyama City Hospital, Fukuchiyama, Kyoto, Japan; 2Department of Health Informatics, Kyoto University School of Public Health, Kyoto, Japan ...
Wada M, Nakayama T, Ishizaki T, Satoh T, Ikeda S   +4 more
doaj  

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source