Results 121 to 130 of about 6,050,843 (300)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

How do teacher support trajectories influence primary and lower-secondary school students' study well-being. [PDF]

Front Psychol, 2023
Ulmanen S, Rautanen P, Soini T, Pietarinen J, Pyhältö K.   +4 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Primary and secondary teachers shaping the science curriculum : the influence of teacher knowledge [PDF]

, 2003
This thesis reports on how primary and secondary teachers' knowledge influenced the implementation of a Year 1-10 science syllabus which was introduced into Queensland in 1999.
Keys, Philip Mark
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The intercultural potential of language activities: Investigating the implementation of intercultural learning in three Austrian EFL textbooks

Intercultural Communication Education
In the context of globalisation, classrooms have become meeting places for learners from an increasing variety of backgrounds. Intercultural education, anchored in many national curricula, is considered a key approach to doing justice to this growing ...
Jasmin Peskoller
doaj   +1 more source

An empirical method to estimate the effect of soil on the rate for transmission of damping‐off disease

, 2004
The ability of some soils to suppress soil-borne diseases has been long recognised, but the underlying epidemiological mechanisms by which this occurs are largely unknown.• Using damping-off disease caused by Rhizoctonia solani, spreading through ...
Alabouvette C, Bailey DJ, C. A. Gilligan, Cook RJ, Dwyer G, Garrett KA, Gilligan CA, Gilligan CA, Gilligan CA, Hoper H, J. A. N. Filipe, Jeger MJ, Kleczkowski A, Nisbet RM, Otten W, Pielaat A, van den Bosch F, Van der Plank JE, W. Otten, Whipps JM   +19 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Generative AI Use Among Slovenian Lower Secondary Students: Use Patterns and Attitudes

Applied Sciences
This study examined lower secondary students’ self-reported use of generative artificial intelligence (GenAI) for schoolwork across four modalities (text, image, audio, and video), and tested how attitudes grounded in the Technology Acceptance Model (TAM)
Barbara Arcet, Kosta Dolenc, Eva Kranjec
doaj   +1 more source

Effect of science virtual laboratory combination with demonstration methods on lower-secondary school students' scientific literacy ability in a science course. [PDF]

Educ Inf Technol (Dordr), 2023
Lestari DP, Supahar, Paidi, Suwarjo, Herianto.   +4 more
europepmc   +1 more source