Results 81 to 90 of about 3,038,209 (307)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Investigation of the relationship between students’ academic achievement and schools’ leadership capacity: An analysis of lower secondary schools in Turkey

KEDI Journal of Educational Policy, 2020
The purpose of this study was to determine lower secondary school students’ academic achievement based on the leadership capacity of schools. The relational survey model was applied using a Turkish adaptation of the Leadership Capacity School Survey with
Gülay Aslan
doaj   +1 more source

Regula falsi in lower secondary school education

Teaching Mathematics and Computer Science, 2016
The aim of this paper is to offer some possible ways of solving word problems in lower secondary school education. Many studies have shown that pupils in lower secondary school education (age 13-14) encounter difficulties with learning algebra. Therefore they mainly use arithmetical and numerical checking methods to solve word problems.
openaire   +1 more source

Lower secondary school students’ understanding of algebraic proof

, 2009
Secondary school students are known to face a range of difficulties in learning about proof and proving in mathematics. This paper reports on a study designed to address the issue of students’ cognitive needs for conviction and verification in algebraic ...
Fujita, Taro, Jones, Keith, Kumakura, Hiroyuki, Kunimune, Susumu   +3 more
core  

Secondary school teachers' attitudes to and beliefs about ability grouping [PDF]

, 2003
Background. Internationally and historically considerable research has been undertaken regarding the attitudes of secondary school teachers towards different types of ability grouping.
Hallam, Susan, Ireson, Judith
core   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Environmental factors of critical thinking formation in lower secondary school students [PDF]

Известия Саратовского университета. Новая серия: Серия Философия. Психология. Педагогика
Introduction. Critical thinking is increasingly in demand in professional activities and private life, however, education systems do not fully answer to the request of its formation yet. The main solution is usually considered to be the implementation of
Koval, Elena G., Yasvin, Vitold A.
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

School Violence Prevention Education for Lower Secondary School Students

East African Scholars Journal of Education, Humanities and Literature
School violence has become an alarming social issue, directly affecting the mental and physical health as well as the overall development of students, especially those at the lower secondary level—a stage marked by significant psychological and behavioral changes.
openaire   +1 more source

Comprehensive versus Selective Schooling in England in Wales: What Do We Know? [PDF]

British secondary schools moved from a system of extensive and early selection and tracking in secondary schools to one with comprehensive schools during the 1960s and 70s.
Alan Manning, Jörn-Steffen Pischke
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