Results 181 to 190 of about 6,075,605 (297)

Clinical Significance of Acute Kidney Injury in Idiosyncratic Drug‐Induced Liver Injury: A Multicentric Propensity Scores Matched Study

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Clinical significance of acute kidney injury in idiosyncratic drug‐induced liver injury: a multicentric propensity scores matched study. Evidence about the role of acute kidney injury (AKI) in idiosyncratic drug‐induced liver injury (DILI) is still scarce.
José María Pinazo‐Bandera   +15 more
wiley   +1 more source

Urogenital Infection Risk Associated With SGLT2 Inhibitors Versus DPP‐4 Inhibitors in Type 2 Diabetes and Chronic Kidney Disease: A Nationwide Target Trial Emulation

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Although sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) are recommended for patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD), concerns regarding urogenital infections persist. Therefore, we evaluated the risk of urinary tract infection (UTI) and genital tract infection (GTI) after SGLT2i initiation in this population ...
Young‐Mi Ah   +4 more
wiley   +1 more source

Morphological signatures of bacteria‐laden drying droplets: A multimodal analysis across host fluids

open access: yesDroplet, EarlyView.
Drying patterns of bacteria‐laden droplets encode concentration‐dependent signatures across three host fluids: serum, urine, and nutrient medium. By integrating time‐evolving texture descriptors, image features, and interpretable multimodal machine learning, this study demonstrates a label‐free approach for extracting information on bacterial ...
Anusuya Pal   +6 more
wiley   +1 more source

Population Pharmacokinetics and Detection Times of Betamethasone After Intravenous, Intramuscular, and Intranasal Jet Administration of Betamethasone Sodium Phosphate in Horses

open access: yesDrug Testing and Analysis, EarlyView.
Betamethasone concentrations in 20 horses from Japan and Germany following IV, IM, and INJ administration of betamethasone phosphate were analyzed using population pharmacokinetic modeling. For IV administration of 0.04 mg/kg q24 h, IPC and IUC were 0.012 and 0.31 ng/mL, respectively; the IUC approximated the IFHA urine ISL (0.20 ng/mL).
Taisuke Kuroda   +9 more
wiley   +1 more source

Supercritical Fluid Chromatography for Expedited Sample Clean‐Up in Isotope Ratio Mass Spectrometry Including Cholesterol as New Endogenous Reference Compound

open access: yesDrug Testing and Analysis, EarlyView.
Supercritical fluid chromatography was employed in the sample preparation for IRMS determinations in sports drug testing for the first time and the developed method was successfully validated. Cholesterol (CHOL) was introduced as a novel endogenous reference compound and population‐based Δ‐values were established as shown here.
Thomas Piper, Jana Drewes, Mario Thevis
wiley   +1 more source

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