Results 171 to 180 of about 125,208 (217)

Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug–drug interactions

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 510-522, March 2025.
Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitoring is suggested for clinical usage of TPM in special population due to its broad side effect profile. Therefore, it is crucial to further explore its pharmacokinetic characteristics.
Shuqing Chen   +6 more
wiley   +1 more source

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

open access: yesPhytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko   +3 more
wiley   +1 more source

Catechins and Their Effect on the Gut Microbiome in Health and Cancer

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Catechins are a group of flavonoids found primarily in green tea, fruits, and berries; they play a significant role in the modulation of the gut microbiota, thereby having an impact on gut health and cancer prevention. Owing to their low bioavailability, catechins are transformed by the gut microbiota into various bioactive metabolites such as
Prakash Monika   +5 more
wiley   +1 more source

Pharmacokinetic and Pharmacodynamic Interactions Between Anti‐Asthma Drugs and Medicinal Plants: A Comprehensive Review

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Asthma affects 260–300 million people worldwide. About 20%–35% of patients use medicinal plants with their asthma medication, often without telling their clinicians. Disclosure rates are low; up to 42% of asthma outpatients use herbal products, with no records in their charts.
Emine Kocyigit   +5 more
wiley   +1 more source

Protective Effects Induced by a Novel Food Supplement Based on Epilobium angustifolium, Ptychopetalum olacoides, Ginkgo biloba, and Equisetum arvense Extracts and Citrulline in the Lower Urinary Tract: Preclinical and Clinical Evidence

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Oxyfil is a dietary supplement including plant extracts from Epilobium angustifolium, Ptychopetalum olacoides (Muira puama), Ginkgo biloba, and Equisetum arvense and citrulline. The aim of the study was to investigate the protective effects on prostatic muscles of the Oxyfil formulation in an in vitro experimental model consisting of isolated ...
Annalisa Chiavaroli   +14 more
wiley   +1 more source

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