Results 101 to 110 of about 655,560 (301)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Increasing productivity through Total Reuse Management (TRM) [PDF]

Total Reuse Management (TRM) is a new concept currently being promoted by the NASA Langley Software Engineering and Ada Lab (SEAL). It uses concepts similar to those promoted in Total Quality Management (TQM).
Schuler, M. P.
core   +1 more source

Silence of the limbs: pharmacological symptomatic treatment of intermittent claudication [PDF]

, 2010
Several oral "vasoactive" drugs claim to increase walking capacity in patients with intermittent claudication (IC). Naftidrofuryl, cilostazol, buflomedil, and pentoxifylline are the most studied molecules.
De Backer, Gui, De Backer, Tine, De Buyzere, Marc, Van Bortel, Lucas, Vander Stichele, Robert   +4 more
core   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Bridging Sales and Services Quality Functions in Retailing of High Technology Consumer Products [PDF]

High technology product sales are positively associated with performance of retailers and distributors in terms of customer service quality, growth in sales and increase in market share.
Rajagopal
core  

Burden of treatment for chronic illness: a concept analysis and review of the literature [PDF]

, 2012
Context Treatment burden, the burden associated with the treatment and management of chronic illness, has not yet been well articulated. Objective Using Rodgers' (1989, Journal of Advanced Nursing, 14, 330–335) method of concept analysis, this review ...
Alwan, Anderson, Australian Institute of Health and Welfare, Bailie, Benner, Bernhard, Brod, Brod, Brod, Brod, Béchetoille, Campbell, Chen, Corona, Fiese, Fried, Gallacher, Gapstur, Graves, Gutierrez-Maldonado, Haugstvedt, Henry, Henry, Kim, Kraker, Longo, Martire, Mathers, Modi, Moss, Nicholl, Olinder, Oude Elberink, Ow, Ribi, Robertson, Rodbard, Rodgers, Rodgers, Thomas, Tjia, Vijan, Walker, Wilcox, World Health Organization, Wysocki, Yoon, Ziaian, Zucca   +48 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

An Analysis of Current Healthcare Proposals: Obama and McCain [PDF]

, 2008
The healthcare system of the U.S. is broken. The next opportunity for overwhelming healthcare system reform will be when the next president takes office.
Terrell, Dan
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Study of affordability of pharmaceutical provision for type 2 diabetes therapy in Ukraine

Medičnì Perspektivi
Increasing the availability and affordability of medical and pharma­ceutical care to the population is the most important task of all levels of government. The purpose of the work is to study the affordability of glucose-lowering drugs for the treatment
I.O. Vlasenko, V.V. Gladyshev, O.M. Zaliska, L.L. Davtian   +3 more
doaj   +1 more source