Results 71 to 80 of about 655,560 (301)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Lower Extremity Peripheral Artery Disease and Quality of Life Among Older Individuals in the Community [PDF]

Journal of the American Heart Association, 2017
Background Evidence regarding the association of lower extremity peripheral arterial disease with quality of life ( QOL ) is mainly from selected clinical populations or relatively small clinical cohorts. Thus, we investigated this association in community‐derived populations.
Aozhou Wu, Josef Coresh, Elizabeth Selvin, Hirofumi Tanaka, Gerardo Heiss, Alan T. Hirsch, Bernard G. Jaar, Kunihiro Matsushita   +7 more
openaire   +3 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Cardiac Rehabilitation in 32-Year-Old Woman with Systemic Lupus Erythematosus Complicated by Constrictive Pericarditis

Acta Medica Bulgarica
The cardiovascular system is severely impacted by systemic lupus erythematosus (SLE), which can cause fibrosis of the pericardium known as constrictive pericarditis (CP).
Hertanto Y., Sarvasti D., Handari S.
doaj   +1 more source

Health-Related Quality of Life among Artisanal Fisherwomen/Shellfish Gatherers: Lower than the General Population [PDF]

International Journal of Environmental Research and Public Health, 2016
Quality of life is an indicator of how well one perceives that he/she is functioning physically and mentally. The aim of this paper is to determine the health-related quality of life (HRQOL) of artisanal fisherwomen/shellfish gatherers from the Saubara municipality in Bahia, Brazil in comparison to the general population. A structured questionnaire was
Juliana Müller, Ila Falcão, Maria Couto, Wendel Viana, Ivone Alves, Denise Viola, Courtney Woods, Rita Rêgo   +7 more
openaire   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Effect of mobile-based cognitive behavior therapy (CBT) on lowering of blood lipid levels in atherosclerotic cardiovascular disease (ASCVD) patients: study protocol for a multicenter, prospective, randomized controlled trial

Trials, 2022
Background Atherosclerotic cardiovascular disease (ASCVD) remains a major source of mortality in China. Convincing evidence has demonstrated that the reduction of low-density lipoprotein cholesterol (LDL-C) is correlated with lowering ASCVD risk.
Xu-Lin Hong, Yi Luan, Hong-Ying Liu, Wen-Bin Zhang   +3 more
doaj   +1 more source

Statins for primary and secondary prevention in the oldest old : an overview of the existing evidence [PDF]

, 2012
Hypercholesterolemia, although a modifiable risk factor for cardiovascular disease, is still one of the leading causes of death among older people in western countries.
Petrovic, Mirko, Van Den Noortgate, Nele, WERBROUCK, BART   +2 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Impact of pegloticase on patient outcomes in refractory gout: current perspectives

Open Access Rheumatology: Research and Reviews, 2018
Rita N Cunha,1 Renata Aguiar,1 Filipa Farinha2 1Rheumatology Department, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal; 2Centre for Rheumatology, University College London, London, UK Abstract: Gout is currently the most frequent cause of ...
Cunha RN, Aguiar R, Farinha F
doaj