Results 91 to 100 of about 555,516 (282)

Design and Synthesis of Peptide‐Polyester Conjugates for Cell‐Mediated Scaffold Degradation

Advanced Healthcare Materials, EarlyView.
This work describes polycaprolactone (PCL)‐based biomaterials engineered to degrade in response to cell‐secreted proteases. A fast‐degrading peptide (Fast) sequence is integrated into a PCL conjugate backbone to produce a biomaterial that is selectively degraded by multiple cell types compared to its scrambled control (ScrFast).
Korina Vida G. Sinad, Natasha K. Hunt, Srujan Singh, Kelly B. Seims, Yingjie Wu, E. Thomas Pashuck, Warren L. Grayson, Lesley W. Chow   +7 more
wiley   +1 more source

Development of a Synthetic Hydrogel to Foster Microvascularization of an Endometriosis Microphysiological System

Advanced Healthcare Materials, EarlyView.
ABSTRACT The ascent of novel alternative methods in drug development spotlights the dual needs for improved biological fidelity to in vivo, along with reproducibility, especially in regulatory applications. The need for pre‐clinical models of patient‐derived endometriosis lesions motivates the development of a vascularizable, completely synthetic ...
Lauren Pruett, Laura Bahlmann, Ryan Ogi, Angela Jiao, Priyatanu Roy, Matthew Johnson, David Trumper, Linda Griffith   +7 more
wiley   +1 more source

Copper–Collagen Interactions Regulate the Mechanical and Invasive Properties of Tumor Spheroids

Advanced Healthcare Materials, EarlyView.
Ionic copper is investigated as a modulator of tumor spheroid growth and invasiveness in a 3D microfluidic glioblastoma model. Copper exposure alters metabolic activity, cytoskeletal organization, protrusion dynamics, and EMT‐related phenotypes in a dose‐ and timing‐dependent manner, revealing how copper bioavailability shapes tumor aggressiveness ...
Paula Guerrero‐López, Jose I. Garcia‐Peiro, Felipe Hornos, Jose L. Hueso, Jesus Santamaria, J. Manuel Garcia‐Aznar   +5 more
wiley   +1 more source

A Predictive Model of the Position of Plasmapause Based on Lunar Phase and Deep Learning Framework

Geophysical Research Letters
The plasmapause position is crucial for understanding magnetospheric dynamics and space weather forecasting. This study pioneers the integration of lunar phase (LP) into plasmapause modeling using two neural network architectures (BP and fully connected ...
Yajun Li, Chao Xiao, Quanqi Shi, Hongtao Huang, Huizi Wang, Anmin Tian, Die Duan, Ganming Ren, Tao Tang, Yang Lin, Chenghao Li, Jiajia Suo   +11 more
doaj   +1 more source

Location-Aware Personalized News Recommendation With Deep Semantic Analysis

IEEE Access, 2017
With the popularity of mobile devices and the quick growth of the mobile Web, users can now browse news wherever they want; so, their news preferences are usually related to their geographical contexts.
Cheng Chen, Xiangwu Meng, Zhenghua Xu, Thomas Lukasiewicz   +3 more
doaj   +1 more source

Designed Liquid Crystalline Nanoassemblies From Clinically Validated Polyunsaturated Lipids for Combined Antioxidant, Anti‐Apoptotic, and Neurotrophic Treatments

Advanced Healthcare Materials, EarlyView.
Ionizable lipid nanoparticles target multiple pathological pathways in neurodegeneration. The designed self‐assembled materials undergo a pH‐triggered structural transformation from a cubosome/hexosome coexistence to a hexosome phase, enhancing intracellular delivery of a multi‐target phytochemical formulation. The antioxidant‐loaded pH‐responsive LNPs
Thelma Akanchise, Fucen Luo, Borislav Angelov, Yuru Deng, Angelina Angelova   +4 more
wiley   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

On Some New Generalized Difference Sequence Spaces of Nonabsolute Type

Journal of Mathematics, 2014
We define a new triangle matrix W^=(wnkλ) by the composition of the matrices Λ=(λnk) and B(r,s,t). Also, we introduce the sequence spaces c0λ(B^),cλ(B^),l∞λ(B^), and lpλ(B^) by using matrix domain of the matrix W^ on the classical sequence spaces c0,c,l∞,
Osman Duyar, Serkan Demiriz, Osman Özdemir   +2 more
doaj   +1 more source

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

Fréchet Envelopes of Nonlocally Convex Variable Exponent Hörmander Spaces

Abstract and Applied Analysis, 2016
We show that the dual Bp·locΩ′ of the variable exponent Hörmander space Bp(·)loc(Ω) is isomorphic to the Hörmander space B∞c(Ω) (when the exponent p(·) satisfies the conditions ...
Joaquín Motos, María Jesús Planells, César F. Talavera   +2 more
doaj   +1 more source