Results 41 to 50 of about 454,775 (287)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

A comparative analysis of computational intelligence algorithms for estimation of LTE channels

open access: yesНаучно-технический вестник информационных технологий, механики и оптики
Precise modelling and accurate estimation of long-term evolution (LTE) channels are essential for numerous applications like video streaming, efficient use of bandwidth and utilization of power.
S. Pathan   +3 more
doaj   +1 more source

Mobilizing the Midstream for Supporting Smallholder Intensification

open access: yesLand, 2022
Most policies and incentives that aim to enable smallholder farmers towards the intensification of their agri-food production systems focus on supply-side strategies, such as training, technical assistance or credit services.
Ruerd Ruben   +2 more
doaj   +1 more source

From LS-PREPOST to LS-DYNA: an introduction: LS-Dyna for beginners with 13 step by step solved examples [PDF]

open access: yes, 2011
LS-DYNA is one of the best explicit finite element application software made by Livermore Software Technology Corporation (LSTC) which is used by engineers to predict impact, crash, and explosions scenarios.
Abid, Hasan M., Shah, Qasim Hussain
core  

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

open access: yesMolecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both   +7 more
wiley   +1 more source

Capital Market Valuation of the Terms of Office of the Chief Executive Officers of Deutsche Telekom After the Initial Public Offering

open access: yesWirtschaftsdienst, 2022
Assuming that CEOs significantly shape a firm’s strategic positioning, the present study looks at two stock-exchange valuation criteria of the largest German telecommunications network operator, Deutsche Telekom, to reflect on the performance of the four
Torsten J. Gerpott, Roman Schwetz
doaj   +1 more source

A 7 000 m Automated Drilling Rig System for Offshore Fixed Platform

open access: yesShiyou jixie
To address the issues of low automation level, harsh working environment and high labor intensity of current offshore modular drilling rigs, an automated drilling rig system suitable for offshore fixed platform was newly developed.
Wang Bing   +6 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Fundamental Laws of the Ultimate State of Objects at the Combined Effects of Multi-Parameter Power Factors and Thermodynamic Environment. Part II

open access: yesМеханика машин, механизмов и материалов, 2015
It is a survey-analytical article, which describes a number of criteria of limit states (LS) of complex objects and identifies methods to measure all the parameters necessary for it practical use.
Leonid A. Sosnovskiy   +5 more
doaj  

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