Results 231 to 240 of about 292,965 (296)

A noncanonical role for Jagged1 in endothelial mechanotransduction

The FEBS Journal, EarlyView.
This study reveals a noncanonical role for Jagged1 in endothelial mechanotransduction. Shear stress modulates Jagged1 expression and subcellular localization. Loss of Jagged1 attenuates mechanotransduction and reduces Src, VEGFR2, and ERK signaling. Direct mechanical stimulation of Jagged1 induces activation of these signaling pathways.
Freddy Suarez Rodriguez, Noora Virtanen, Elmeri Kiviluoto, Rob C. H. Driessen, Feihu Zhao, Carlijn V. C. Bouten, Oscar M. J. A. Stassen, Cecilia M. Sahlgren   +7 more
wiley   +1 more source

Improving access to rare disease diagnostics in Africa: insights from a multinational pilot study. [PDF]

Orphanet J Rare Dis
Swanepoel AC, Hendriksz CJ, Mukhwana R, Oduwole A, Abdalla AT, Ameyaw E, Muze KC, Auruku A, Pinto F, Joel D, Aleksovska V, Collin-Histed T, Odero R, Conradie EH.   +13 more
europepmc   +1 more source

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

Immunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu, Jan Gärtig, Stephan Eiber, Stefan Moder, Raffael Thaler, Matthias Thaler, Juliane Gruen, Marlies Vornhülz, Kevin Bahner, Luana Messa, Benjamin Kühnemuth, Jennifer Müller, Konstantin Schnell, Antonia Beimert, Carolin Perleberg, Natascha Röhrle, Maximilian Martin Ludwig Knott, Linda Hammann, Vanessa Wittmann, Patrick Layritz, Moritz Rapp, Carole Bourquin, Julia Mayerle, Stefan Endres, David Anz   +24 more
wiley   +1 more source

Psychedelics as Novel Therapeutics for Chronic Pain in Veterinary Medicine: A Hypothesis-Driven Protocol Using Low-Dose 1-Cyclopropionyl-D-lysergic Acid Diethylamide (1cp-LSD) in Canine Osteoarthritis. [PDF]

Animals (Basel)
Hernández-Álvarez E, Acosta-Dacal A, Luzardo OP, Henríquez-Hernández LA.   +3 more
europepmc   +1 more source

Lumpy Skin Disease Virus Infected Calves Showing Multisystemic Vasculitis on Postmortem Examination: A Summary of Six Cases. [PDF]

Transbound Emerg Dis
Jerin I, Hossain MR, Tasnim S, Rahman SM, Globig A, Hoffmann B, Chowdhury EH, Parvin R.   +7 more
europepmc   +1 more source

Simple Analogs of the LSD D-Ring: A Consideration of Structure-Activity Relationships and Their Potential as Therapeutics. [PDF]

ACS Chem Neurosci
Barker SA.
europepmc   +1 more source

Constitutive AMPK activation prevents hepatocellular carcinoma development through inhibition of HNF4α activity. [PDF]

Sci Adv
Sun Z, Linares B, Urdiales C, Alsarmi F, Sang B, Putluri N, Van Nostrand JL.   +6 more
europepmc   +1 more source

Genetic Characterization of the First Case of Lumpy Skin Disease in Singapore, 2022. [PDF]

Vet Sci
Koh EY, Tan AKS, Ip YCA, Lau C, Ong J, Ng OW, Chen J, Lee C, Fabbri S, Chua J, Balakumar S, Ho K, Wong WK, Tan BZY, Fernandez CJ, Chang SF, Yap HH.   +16 more
europepmc   +1 more source

Quantitative analysis of the correlation between extraforaminal structures of lumbar spondylolisthesis and L5 nerve injury. [PDF]

J Orthop Surg Res
Guo Y, Liu X, Jia F, Yang H, Cui X.
europepmc   +1 more source