Results 51 to 60 of about 482,764 (277)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

The Effect of Anaerobic Digestate on the Soil Organic Carbon and Humified Carbon Fractions in Different Land-Use Systems in Lithuania

Land, 2022
The most important component of agricultural system are soils as the basis for the growth of plants, accumulation of water, plant nutrients and organic matter. The main task of our research was to ascertain changes in soil organic carbon (SOC) and mobile
Alvyra Slepetiene, Mykola Kochiieru, Linas Jurgutis, Audrone Mankeviciene, Aida Skersiene, Olgirda Belova   +5 more
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Isolation of Biologically Active Compounds from Cannabis sativa L. Inflorescences by Using Different Extraction Solvents and Evaluation of Antimicrobial Activity

Antioxidants, 2023
Hemp inflorescences are a source of vital compounds, including phytocannabinoids and other biologically active compounds. Various methods are adapted for the extraction of these vital compounds such as the use of different organic solvents.
Dovilė Motiejauskaitė, Sana Ullah, Algimanta Kundrotaitė, Renata Žvirdauskienė, Aušra Bakšinskaitė, Karolina Barčauskaitė   +5 more
doaj   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Endometrial cancer and microsatellite instability status

Open Medicine, 2014
Microsatellite instability (MSI) is an important factor in the development of various cancers as an identifier of a defective DNA mismatch repair system.
Kanopiene Daiva, Vidugiriene Jolanta, Povilas Valuckas Konstantinas, Smailyte Giedre, Uleckiene Saule, Bacher Jeff   +5 more
doaj   +1 more source

A Systematic Review of Candidate Genes for Major Depression

Medicina, 2022
Background and Objectives: The aim of this systematic review was to analyse which candidate genes were examined in genetic association studies and their association with major depressive disorder (MDD).
Audrone Norkeviciene, Romena Gocentiene, Agne Sestokaite, Rasa Sabaliauskaite, Daiva Dabkeviciene, Sonata Jarmalaite, Giedre Bulotiene   +6 more
doaj   +1 more source

Topological magnon bound-states in periodically modulated Heisenberg XXZ chains

, 2017
Strongly interacting topological states in multi-particle quantum systems pose great challenges to both theory and experiment. Recently, bound states of elementary spin waves (magnons) in quantum magnets have been experimentally observed in quantum ...
Ke, Yongguan, Lee, Chaohong, Mei, Feng, Qin, Xizhou, Zhang, Li   +4 more
core   +1 more source

Cognitive Status in People With Epilepsy in the Republic of Guinea: A Prospective, Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick, Cheick O. Soumah, Malé Doré, Oumar Mara, Desiré Neldje, Fodé A. Cissé, Toure M. Lamine, Aminata Diallo, Seungwon Lee, Siddharth Satish, Alexander J. X. Chen, Alice Liu, Nomin Enkhtsetseg, Farrah J. Mateen, The Guinea Epilepsy Project   +14 more
wiley   +1 more source

PENURUNAN TOTAL BAKTERI DAGING AYAM DENGAN PERLAKUAN PERENDAMAN INFUSA DAUN SALAM (Syzygium polyanthum)

Jurnal MIPA, 2014
Daun salam (Syzygium polyanthum) merupakan salah satu tanaman antibakteri karena mengandung senyawa flavonoid, tannin, dan minyak atsiri. Tujuan penelitian ini untuk mengetahui pengaruh perendaman infusa daun salam terhadap penurunan jumlah bakteri pada ...
A Kusumaningrum, P Widiyaningrum, I Mubarok   +2 more
doaj