Results 171 to 180 of about 626,146 (282)

A Multifaceted Interplay Among Hemophagocytosis, Interleukin‐18, and Type I Interferon Distinguishes Still Disease From Other Autoinflammatory Diseases

Arthritis &Rheumatology, EarlyView.
Objective The unknown pathophysiology and the lack of specific features for systemic juvenile idiopathic arthritis and adult‐onset Still disease (collectively known as Still disease; SD) delay diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that distinguish SD from other systemic autoinflammatory ...
Yvonne M. Mueller, Charlotte Girard, Harmen J. G. van de Werken, Stefan J. Erkeland, Dwin G. B. Grashof, Laurie Vaillant, Renske J. H. den Dekker, Iris van Zuijen, Sharon Veenbergen, Fanny Coffin, Eric Bindels, Yvan Jamilloux, Katerina Laskari, Vassili Soumelis, Bruno Fautrel, Cem Gabay, Peter D. Katsikis   +16 more
wiley   +1 more source

Prevalence and Risk Factors of Ocular Hypertension Following Fluocinolone Acetonide (Iluvien^®) Intravitreal Injections: The "SAFAC" Study. [PDF]

Ophthalmol Ther
Serrar Y, Sejournet L, Allignet B, Bounetta S, Deiri M, Gullon C, Malclès A, Denis P, Mathis T, Kodjikian L.   +9 more
europepmc   +1 more source

Nerve growth factor is sufficient to cause multiple osteoarthritis‐relevant pathological features in naïve murine knee joints

Arthritis &Rheumatology, Accepted Article.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped due to side‐effects in the joints. Knowledge about the biological effects of NGF on joint tissues is limited.
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source

Reliability of Simplified Versions of Enhanced Recovery After Surgery (ERAS) in Colorectal Surgery: A Retrospective Cohort Study. [PDF]

Cureus
Olive M, Moisés de Almeida Leite R, Jacomino LFB, Tustumi F, Portilho AS, Vaz Pandini R, Cata Preta Stozlemburg L, Seid VE, De Araújo Horcel L, Araujo SE.   +9 more
europepmc   +1 more source

Single‐Stage Repair of Complex Anterolateral Radial and Posterior Root Tears of the Lateral Meniscus, With a Concomitant Multiligament Knee Reconstruction of the Anterior Cruciate Ligament, Medial Collateral Ligament, Posterior Oblique Ligament, and Anterolateral Ligament in a Young Athlete

Arthroscopy Techniques, EarlyView.
Abstract Early meniscal repair and anatomic reconstruction in a multiligament knee injury optimizes outcomes and restores tibiofemoral mechanics. This technique describes a lateral meniscus posterior root and radial tear repair, with concomitant medial ramp repair, performed during single‐stage reconstruction of the anterior cruciate ligament ...
Romir Patel, Sarah L. Larson, Benjiman J. Wilebski, Luke V. Tollefson, Matthew T. Rasmussen, Dustin R. Lee, Robert F. LaPrade   +6 more
wiley   +1 more source

Genetic Surveillance Reveals Differential Evolutionary Dynamic of Anopheles gambiae Under Contrasting Insecticidal Tools Used in Malaria Control. [PDF]

Mol Ecol
Njoroge HN, Namuli L, Nagi SC, Hernandez-Koutoucheva A, McDermott DP, Knight E, Gonahasa S, Lynd A, Oruni A, Maiteki-Sebuguzi C, Opigo J, Yeka A, Katureebe A, Kyohere M, Kamya MR, Dorsey G, Hemingway J, Staedke SG, Clarkson C, Miles A, Lucas ER, Donnelly MJ.   +21 more
europepmc   +1 more source

Model‐informed drug development to support nemolizumab clinical development in adults and adolescents with moderate to severe atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Population pharmacokinetic (popPK) and pharmacokinetic‐pharmacodynamic (PK/PD) models were developed to support clinical development of nemolizumab, a humanized monoclonal antibody targeting the IL‐31 receptor α, in adolescents and adults with moderate‐to‐severe atopic dermatitis (AD).
Floris Fauchet, Anna Largajolli, Petra M. Jauslin, Emilie Schindler, Mourad Hamimed, Wannee Kantasiripitak, Antonio Gonçalves, Eline Van Maanen, Khaled Benkali, Tomohisa Saito, Jonathan I. Silverberg, Andreas Wollenberg, Michael Graeber, Liliana Ulianov, Christophe Piketty, Luca Loprete, Vincent Duval, Nathalie Wagner   +17 more
wiley   +1 more source

Unraveling the nexus: Tumor mutational burden, PD-L1 expression, and oncogenic alterations in non-small cell lung cancer cytology specimens. [PDF]

Cancer Cytopathol
Dai M, San Lucas FA, Alvarez H, Ballester L, Chen H, Patel KP, Rashid A, Rao S, Routbort MJ, Sura G, Sweeney K, Toruner G, Wei P, Yang R, Dang H, Luthra R, Roy-Chowdhuri S.   +16 more
europepmc   +1 more source

Completion vs. early discontinuation of chemotherapy and the impact on 5‐year all‐cause mortality in women treated for early‐stage breast cancer from 2015 to 2020: A cohort study using a target trial emulation approach

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Chemotherapy is given for early‐stage breast cancer; however, some patients discontinue before completing all planned cycles. This study investigated the impact of early chemotherapy discontinuation on treatment outcomes. Methods This retrospective cohort study used a target trial emulation framework to conduct a causal analysis of the all‐
Luke Steventon, Chengsheng Ju, Kenneth K. C. Man, Rebecca Roylance, Diego Ottaviani, Chiara Creed, Michal Sladkowski, Alec Wisner, Li Wei, Pinkie Chambers   +9 more
wiley   +1 more source

"Long-term outcomes of ventral hernia repair using heavyweight non-woven polypropylene mesh". [PDF]

Hernia
Risser KM, Schmidt EM, Woo KP, Beffa LRA, Prabhu AS, Krpata DM, Rosen MJ, Petro CC, Miller BT.   +8 more
europepmc   +1 more source