Results 231 to 240 of about 10,886,718 (351)

Investigating the Ligand‐Binding Properties of N‐arylbenzimidazoles as Novel Elastase Inhibitors

ChemMedChem, EarlyView.
A series of novel N‐[(3,5‐dimethylphenyl)methyl]‐1H‐benzimidazole derivatives is designed, synthesized, and evaluated for inhibitory activity against elastase. Several compounds demonstrate an antielastase activity, including the N‐(2‐bromophenyl)‐2‐(6‐chloro‐1‐(3,5‐dimethylbenzyl)‐1H‐benzo[d]imidazol‐2‐ylthio)acetamide, showing the greatest potency ...
Giovanna Pitasi, Sonia Floris, Francesca Mancuso, Giulia Savoca, Rosaria Gitto, Antonella Fais, Laura De Luca   +6 more
wiley   +1 more source

Minimally-Invasive Conventional Right Colectomy Versus Complete Mesocolic Excision for Right-Colon Adenocarcinoma: A Single-Institution Cohort. [PDF]

Cureus
Moisés de Almeida Leite R, Pilotto Ramos L, Portilho AS, Tustumi F, Cata Preta Stozlemburg L, Soares Gerbasi L, de Araújo Horcel L, Vaz Pandini R, Seid VE, Araujo S.   +9 more
europepmc   +1 more source

Spectroscopic Reactor for Operando Investigations Made by Additive Manufacturing for High‐Pressure Catalysis Applications

Chemistry–Methods, EarlyView.
A spectroscopic reactor for operando X‐ray studies under high‐pressure conditions is developed and fabricated via additive manufacturing. Its two‐zone design allows independent temperature control and catalyst loading, enabling studies at different conversion levels. A large window permits spatially‐resolved X‐ray analysis.
Mariam L. Schulte, Vera Truttmann, Lorena Baumgarten, Alexander G. Nicolai, Diego A. Montalvo Beltran, Florian J. Summ, Christoph Kiener, Erisa Saraçi, Jan‐Dierk Grunwaldt   +8 more
wiley   +1 more source

Revisiting CN− Formation Mechanisms in Electron Collisions with Benzonitrile

ChemPhysChem, EarlyView.
This study explores negative ion formation via electron attachment, revealing CN− formation at 3.0 and 7–10 eV. Dissociation pathways are analyzed using G4(MP2) and CASPT2 calculations, highlighting the coupling between the π4* and σ* resonances critical for interstellar chemistry. Radiation‐induced processes in the aromatic cyano compound benzonitrile
Rodrigo Rodrigues, Mónica Mendes, Daniel Bou‐Debes, João Ameixa, Ali Kamali, Oddur Ingólfsson, Samuel Eden, Lucas M. Cornetta, Filipe Ferreira da Silva   +8 more
wiley   +1 more source

The body sends a signal: Perspectives on interoception. [PDF]

PLoS Biol
Smith LK, PLOS Biology staff editors.
europepmc   +1 more source

Capability Development in the European Medicines Regulatory Network—A European Learning Needs Analysis and Survey Study

Clinical Pharmacology &Therapeutics, EarlyView.
The European Medicines Regulatory Network plays a critical role in safeguarding public health through the assessment and supervision of human medicines. However, rapid scientific and technological advancements have exposed capability deficits across the network, threatening timely and effective regulatory decision‐making.
Naomi Beard, Marko J. Kallio, Luca Kosec, Ulrika Espefält Westin, on behalf of the IncreaseNET consortium   +4 more
wiley   +1 more source