Results 41 to 50 of about 31,122 (260)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Diophantine equations with Lucas and Fibonacci number coefficients [PDF]

Notes on Number Theory and Discrete Mathematics
Fibonacci and Lucas numbers are special number sequences that have been the subject of many studies throughout history due to the relations they provide.
Cemil Karaçam, Alper Vural, Bilal Aytepe, Ferhat Yıldız   +3 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

A Study on Dual Hyperbolic Fibonacci and Lucas Numbers

Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2019
In this study, the dual-hyperbolic Fibonacci and dual-hyperbolic Lucas numbers are introduced. Then, the fundamental identities are proven for these numbers.
Cihan Arzu, Azak Ayşe Zeynep, Güngör Mehmet Ali, Tosun Murat   +3 more
doaj   +1 more source

The Lucas property of a number array

Discrete Mathematics, 2002
Let \(p\) be a prime and \(\alpha\), \(\beta\), \(\gamma\), \(\delta\) be nonnegative integers such that \(0\leq \beta< p\) and \(0\leq\delta< p\). A double integer number array \(N(i,j)\), where \(i\) and \(j\) are nonnegative integers, is said to satisfy the Lucas property, if \(N(\alpha p+\beta, \gamma p+\delta)\equiv N(\alpha, \gamma)N(\beta,\delta)
openaire   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Bi-Periodic (p,q)-Fibonacci and Bi-Periodic (p,q)-Lucas Sequences

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2023
In this paper, we define bi-periodic (p,q)-Fibonacci and bi-periodic (p,q)-Lucas sequences, which generalize Fibonacci type, Lucas type, bi-periodic Fibonacci type and bi-periodic Lucas type sequences, using recurrence relations of (p,q)-Fibonacci and (p,
Yasemin Taşyurdu, Naime Şeyda Türkoğlu   +1 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Non-Newtonian Pell and Pell-Lucas numbers

Journal of New Results in Science
In the present paper, we introduce a new type of Pell and Pell-Lucas numbers in terms of non-Newtonian calculus, which we call non-Newtonian Pell and non-Newtonian Pell-Lucas numbers, respectively.
Tülay Yağmur
doaj   +1 more source