Results 171 to 180 of about 248,402 (331)

Derivatization of Small Molecules using Deuterated Analog of Reactive Matrix to Facilitate Identification in Mass Spectrometry Imaging

open access: yesChemistry–Methods, EarlyView.
The deuterated FMP‐10 analog, FMP‐10‐d3, enhances identification through isotopic labeling, providing structural insights via unique mass shifts. The approach improves the analysis of neurotransmitters and metabolites, facilitating neurochemical mapping and spatial metabolomics, with applications in neurodegenerative disease research. Mass spectrometry
Theodosia Vallianatou   +7 more
wiley   +1 more source

Results of the ACCOuNT Trial: A Multi‐Institutional Prospective Pharmacogenomics Implementation Trial for African American Inpatients

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Pharmacogenomics implementation efforts have increased over the last decade, but no published prospective pharmacogenomics trials have formally evaluated utility in underrepresented populations. We present final results from the ACCOuNT trial, a multi‐institutional prospective study [NCT03225820] in which African American inpatients were genotyped and ...
Zhong Huang   +17 more
wiley   +1 more source

The challenge of ultra‐rarity: Dual diagnosis of Lafora disease and developmental encephalopathies linked to TRIO and SHANK3 pathogenic variants

open access: yesEpilepsia Open, EarlyView.
Abstract We report two cases of dual genetic diagnoses involving Lafora disease (LD) and co‐occurring neurodevelopmental disorders caused by pathogenic variants in TRIO and SHANK3, respectively. LD is an ultra‐rare, autosomal recessive, severe form of progressive myoclonus epilepsy affecting previously healthy children or adolescents. In both patients,
Lorenzo Muccioli   +29 more
wiley   +1 more source

Sign-alternating Gibonacci polynomials [PDF]

open access: yesEnumerative Combinatorics and Applications, 2021
Robert G. Donnelly   +3 more
doaj  

Resist!: Sustaining forest carbon sequestration and wood production after insect disturbance

open access: yesFrontiers in Ecology and the Environment, EarlyView.
Disturbances from insect pests threaten ecologically and economically important goods and services supplied by forests, including wood production and carbon sequestration. We highlight the factors that influence these services’ resistance, a term quantifying the initial response to disturbance.
Christopher M Gough   +14 more
wiley   +1 more source

Gut Microbiota‐Bile Acid Metabolism Axis Drive Anti‐Diabetic Effects of Polygonatum cyrtonema Polysaccharide on Glycolipid Metabolism and Intestinal Inflammation

open access: yesFood Frontiers, EarlyView.
PCP‐80% could lessen the pathophysiology of T2DM in terms of controlling blood glucose/lipid levels and enhancing intestinal barrier function, via modulating the intricate web of intestinal microbiota/BAs/BAs signaling pathways. Red vertical arrows denote increases (HPCP‐80% vs. MC), blue vertical arrows indicate decreases (HPCP‐80% vs.
Xiaole Zhao   +8 more
wiley   +1 more source

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