Results 151 to 160 of about 613,108 (397)
Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
wiley +1 more source
‘That’s unscientific!’: Science as the arbitrator of ‘truth’ in (German) feminist linguistic debates [PDF]
, 2014 The feminist critique of language has been contested from its very inception. Opponents have distanced themselves from feminist proposals by arguing, for example, that language and reality are separate entities; that linguistic disparity is insignificant
Luck, C
core
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Why shape matters in granular compaction [PDF]
Journal of Physics A 36 (2003), L365-L372, 2002 We present a stochastic model of dynamically interacting grains in one dimension, in the presence of a low vibrational intensity, to investigate the effect of shape on the statics and dynamics of the compaction process. Regularity and irregularity in grain shapes are shown to be centrally important in determining the statics of close-packing states, as
arxiv
Hippokratischer Eid für Naturwissenschaftler: Ein Gespräch mit Dr. Luck (Ludwigshafen) [PDF]
, 1962 openalex +1 more source
Killer Whale Ecotypes in the Juneau Area [PDF]
, 2017 The goal of this project was to identify the most common killer whale ecotype in the Juneau area. Over 400 photographs of killer whales taken from the years 2012-2015 were collected from Juneau photographers and marine naturalists on various whale ...
Luck, Emma
core
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
Hikers in Flip‐Flops: Luck Egalitarianism, Democratic Equality and the Distribuenda of Justice
, 2016 The article has two aims. First, to show that a version of luck egalitarianism that includes relational goods amongst its distribuenda can, as a matter of internal logic, account for one of the cor ...
Anca Gheaus
semanticscholar +1 more source
Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
Demotivating Semi-Compatibilism
Ideas y Valores, 2009 In this paper, I explore some of the motivations behind John Martin Fischer's semi-compatibilism. Particularly, I look at three reasons Fischer gives for preferring semi-compatibilism to libertarianism. I argue that the first two of these motivations are
Kevin Timpe
doaj