Results 201 to 210 of about 124,017 (271)

L‐type Voltage‐Gated calcium channels partly mediate Mechanotransduction in the intervertebral disc

open access: yesJOR SPINE, Volume 5, Issue 4, December 2022., 2022
This study investigated the expression and function of voltage‐gated ion channels in the intervertebral disc. One channel, Cav2.2, was found to be upregulated in degeneration, while L‐type voltage gated calcium channels were found to be involved in mediating calcium signaling and the response of disc cells to dynamic compression.
Philip Poillot   +3 more
wiley   +1 more source

The effects produced by unilateral lumbar sympathectomy [PDF]

open access: bronze, 1930
Gary McCullagh   +2 more
openalex   +1 more source

Effects of perampanel on bone health in adult patients with epilepsy

open access: yesEpilepsia Open, EarlyView.
Abstract Objective The objective was to assess the effects of perampanel (PER) on bone metabolism and bone mineral density (BMD) in adult patients with epilepsy. Methods This retrospective study included consecutive patients admitted to the Epilepsy Center of Sichuan Provincial People's Hospital from January 2023 to June 2024.
Mingxing Yu   +8 more
wiley   +1 more source

Influence of patient‐specific factors when comparing multifidus fat infiltration between chronic low back pain patients and asymptomatic controls

open access: yesJOR SPINE, Volume 5, Issue 4, December 2022., 2022
Many studies have attempted to link multifidus fat infiltration with muscle quality and chronic low back pain, but there is no consensus on these relationships. This study suggests that when the presence of fat is not characteristic of an individual's age, sex, and BMI, it may be a back pain risk factor.
Alexander M. Ballatori   +10 more
wiley   +1 more source

N‐acetylcysteine attenuates oxidative stress‐mediated cell viability loss induced by dimethyl sulfoxide in cryopreservation of human nucleus pulposus cells: A potential solution for mass production

open access: yesJOR SPINE, Volume 5, Issue 4, December 2022., 2022
N‐acetylcysteine attenuates DMSO induced oxidative stress mediated viability loss in NP cells. Abstract Background Cell therapy is considered a promising strategy for intervertebral disc (IVD) regeneration. However, cell products often require long‐term cryopreservation, which compromises cell viability and potency, thus potentially hindering ...
Shota Tamagawa   +11 more
wiley   +1 more source

PHLPP1 deficiency protects against age‐related intervertebral disc degeneration

open access: yesJOR SPINE, Volume 5, Issue 4, December 2022., 2022
PH domain leucine‐rich‐repeats protein phosphatase (PHLPP1) deficiency protected against NP phenotypic changes, extracellular matrix degradation, and cell apoptosis in the process of intervertebral disc (IVD) degeneration, making PHLPP1 a promising therapeutic target for treating IVD degeneration.
Changli Zhang   +5 more
wiley   +1 more source

Fibrotic and inflammatory characteristics of epidural fat adjacent to the ossification area in patients with ossification of the ligament flavum

open access: yesJOR SPINE, Volume 5, Issue 4, December 2022., 2022
We observed the histological and inflammatory characteristics of epidural fat (EF) adjacent to the ossification area in patients with ossification of the thoracic ligament flavum (TOLF) and provide a preliminary basis for investigating the impact of EF on OLF. Morphologically, EF exhibits no significant differences between the TOLF and non‐TOLF groups,
Xinyu Dou   +5 more
wiley   +1 more source

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