Results 211 to 220 of about 368,129 (296)

Intraputaminal Delivery of Adeno‐Associated Virus Serotype 2–Glial Cell Line–Derived Neurotrophic Factor in Mild or Moderate Parkinson's Disease

open access: yesMovement Disorders, EarlyView.
Abstract Background Glial cell line–derived neurotrophic factor (GDNF) is required for development and survival of dopaminergic neurons. A previous trial evaluating lower‐dose adeno‐associated virus serotype 2–GDNF (AAV2‐GDNF) bilateral intraputaminal infusion in participants with advanced Parkinson's disease (PD) achieved 26% mean putaminal coverage ...
Amber D. Van Laar   +10 more
wiley   +1 more source

Corticospinal Tract Development, Evolution, and Skilled Movements

open access: yesMovement Disorders, EarlyView.
Abstract The evolution of the corticospinal tract (CST) is closely linked to the development of skilled voluntary movements in mammals. The main evolutionary divergence concerns the position of the CST within the spinal cord white matter and its postsynaptic targets in the grey matter.
Emmanuel Roze   +2 more
wiley   +1 more source

Capture of Longitudinal Change in Real‐Life Walking in Cerebellar Ataxia Increases Patient Relevance and Effect Size

open access: yesMovement Disorders, EarlyView.
ABSTRACT Background With disease‐modifying drugs for degenerative ataxias on the horizon, ecologically valid measures of gait performance that can detect patient‐relevant changes in trial‐like time frames are highly warranted. Objectives In this 2‐year longitudinal study, we aimed to unravel ataxic gait measures sensitive to longitudinal changes in ...
Jens Seemann   +8 more
wiley   +1 more source

A Systematic Review of Attributes Influencing Preferences for Treatments and Interventions in People With Amyotrophic Lateral Sclerosis (ALS)

open access: yesMuscle &Nerve, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that has no cure, and treatments predominantly focus on improving quality of life. Patient‐centred care is central to bringing about meaningful improvements to quality of life.
A. Clift   +4 more
wiley   +1 more source

Medical nutrition therapy in chronic obstructive pulmonary disease: A narrative review

open access: yesNutrition in Clinical Practice, EarlyView.
Abstract Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous lung condition characterized by persistent airflow obstruction, associated with cardiovascular, metabolic and musculoskeletal comorbidities. In 2022, approximately 480 million people were affected by this disease, making it the third leading cause of mortality ...
Patricia Savino‐Lloreda   +2 more
wiley   +1 more source

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