Results 71 to 80 of about 390,913 (299)

Importance of microstructure of lumbar pedicle in screw placement

National Journal of Clinical Anatomy, 2012
Background and objective: Any structural deviation of the pedicle may result in interference of the weight transmission mechanism and compression of neural structures.
Kunal Chawla, Mahesh Sharma, Avinash Abhaya, Ratesh Kumar, Jyotsna Singh   +4 more
doaj   +1 more source

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

In Vivo Measurements Reveal Increased Nucleus Pulposus Lactate and Oxygen Concentrations in a Goat Model of Intervertebral Disc Degeneration

JOR Spine
Introduction Intervertebral disc degeneration is strongly implicated as a cause of low back pain. Although the precise pathophysiological mechanisms remain elusive, perturbations in nutrition that adversely impact the cellular microenvironment of the ...
Karthikeyan Rajagopal, Thomas P. Schaer, Kyle D. Meadows, Madeline Boyes, Rachel Hilliard, John C. O'Donnell, George R. Dodge, Dmitriy Petrov, Dawn M. Elliott, Robert L. Mauck, Lachlan J. Smith, Neil R. Malhotra   +11 more
doaj   +1 more source

Early pathological alterations of lower lumbar cords detected by ultrahigh-field MRI in a mouse multiple sclerosis model [PDF]

, 2013
Yuki Mori, Masaaki Murakami, Yasunobu Arima, Dasong Zhu, Yasuo Terayama, Yutaka Komai, Yuji Nakatsuji, Daisuke Kamimura, Yoshichika Yoshioka   +8 more
openalex   +1 more source

Inhibition of Hypersialylation in Human Intervertebral Disc Degeneration Modulates Inflammation and Metabolism

Advanced Science, EarlyView.
Glycosylation, specifically hypersialylation, is identified as a critical factor in human intervertebral disc (IVD) degeneration—a major cause of low back pain. This study demonstrates that inhibiting sialylation reduces inflammation and oxidative stress in IVD tissues, suggesting new therapeutic possibilities.
Kieran Joyce, Aert F. Scheper, Aung Myat Phyo, Roisin O’ Flaherty, Richard Drake, Aiden Devitt, Martina Marchetti‐Deschmann, Radka Saldova, Abhay Pandit   +8 more
wiley   +1 more source

Prevalence and distribution of Modic Changes and association with low back pain: a descriptive analysis

Bone & Joint Open
Aims: This study examines the prevalence and distribution of Modic changes (MCs) in the lumbar spine and the association with low back pain (LBP) across different age and sex categories.
Mohamed A. Shazahan, Alistair Stirling, Adrian Gardner   +2 more
doaj   +1 more source

Utilization of anterior lumbar interbody fusion for severe kyphotic deformity secondary to Pott’s disease: illustrative case [PDF]

, 2021
Gabrielle Luiselli, Rrita Daci, Peter Cruz‐Gordillo, Ashwin Kumar Panda, Omar Sorour, Justin Slavin   +5 more
openalex   +1 more source

Nanogel Integrated Zwitterionic Injectable Hydrogel with Sequential Drug‐Releasing Capability for the Programmable Repair of Spinal Cord Injury

Advanced Science, EarlyView.
A novel drug‐loaded D/P‐g‐PSB nanogel‐incorporated hydrogel by the electrostatic attraction‐driven self‐assembling process. Sequential drug releasing property (melatonin is released first by physical diffusion, and then ibuprofen is released as the charge shielding effect and hydrogel degradation). This ion‐sensitive hydrogel platform with sequentially
Zhijian Wei, Susu Huang, Wencan Zhang, Jiayao Wen, Xiaolong Zhou, Wei He, Xiaoye Yang, Haifeng Wang, Guangxi Zhai, Bin Shi, Lin Jin, Dachuan Wang, Shiqing Feng, Lei Ye   +13 more
wiley   +1 more source

Adaptation of thoracic and lumbar curvature and spinal muscle activity under changing gravity

Frontiers in Physiology
IntroductionThe effect of micro-gravity on the lumbar and in particular thoracic regions is poorly understood. The aim of this study was to evaluate spinal curvature across the lumbar and thoracic region, and extensor muscle activity during acute micro ...
Anita Meinke, Alessandro Longhi Baez, Niklas Wiesmann, Oliver Ullrich, David A. Green, David A. Green, Marcel Egli, Marcel Egli, Jaap Swanenburg, Jaap Swanenburg   +9 more
doaj   +1 more source

Minimal Invasive Transforaminal Lumbar Interbody Fusion for Isthmic Spondylolisthesis with Nerve Root Anomaly in Young Adult Male Football Player: Case Report [PDF]

, 2021
Umesh Srikantha, Yadhu K. Lokanath, Akshay Hari, Ravi Gopal Varma, Consultant Neurosurgeon, R Trimba, J Spivak, J Bendo, F Postacchini, S Urso, L Ferro, N Babayeva, S Torgutalp, G Et Dnmez, Al, G Scuderi, A Vaccaro, G Brusovanik, L Kadish, E Simmons, S Song, J Lee, J Choi, C Kang, M Shin, S Kim, D Davidson, R Rowan, C Reilly, W Hutton, B Cyron, Spondylolysis, A Ganju, A Moskowitz, M Shane, G Mina, J Kryzanski, S Srikantha, Y Lokanath, A Hari, R Varma   +40 more
openalex   +1 more source