Results 1 to 10 of about 3,946 (103)
Impact of Unilateral Sciatica Due to Lumbar Disc Hernia on Gait [PDF]
HealthcarePedro V. Munuera +2 more
exaly +2 more sources
Advanced Science, EarlyView.IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia +8 more
wiley +1 more source
Advanced Science, EarlyView.This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen +9 more
wiley +1 more source
Advanced Science, EarlyView.Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin +23 more
wiley +1 more source
Advanced Science, EarlyView.The engineered MMS@TRP microgel enables targeted, acid‐responsive delivery of a miR‐21 inhibitor to pericytes. It effectively suppresses disc fibrosis by inhibiting TGF‐β signaling while protecting nucleus pulposus cells via sustained, antioxidant tannic acid release.
Fei Ma +12 more
wiley +1 more source
Head &Neck, EarlyView.ABSTRACT Background Head and neck reconstructive and plastic surgery exposes surgeons to prolonged static posture, sustained visualization of a narrow operative field, cervical and shoulder loading, fine‐motor work, and extended standing. These demands create a substantial occupational musculoskeletal burden.
Babak Shadgan +5 more
wiley +1 more source
Ibrain, Volume 11, Issue 1, Page 106-111, Spring 2025.A middle‐aged man presented with a right indirect inguinal hernia in November 2020 and underwent laparoscopic high ligation of the right hernial sac. Intermittent acupuncture‐like pain in the skin of the right scrotum and medial thigh occurred 1 month after surgery and lasted for 6 months. Under ultrasound guidance, ilioinguinal nerve and genitofemoral
Yong Wang +4 more
wiley +1 more source
Veterinary Record, EarlyView.Abstract Background Osteoarthritis (OA) causes chronic pain and reduces welfare in dogs. Standard treatments may be inadequate or associated with adverse effects, prompting investigation of alternative therapies. Transcutaneous electrical nerve stimulation (TENS) is a non‐pharmacological pain management method, but evidence for its efficacy in canine ...
Anja Pedersen +5 more
wiley +1 more source
Canadian evidence‐based guidelines on spinal procedures for chronic pain
Anaesthesia, EarlyView.Summary Introduction Interventional procedures are commonly used to diagnose and treat chronic pain of spinal origin but guidance on: their indications; frequency; technical conduct; requirements for image guidance; outcome measurement; and management of complications is lacking.
Anuj Bhatia +26 more
wiley +1 more source
Acta Obstetricia et Gynecologica Scandinavica, EarlyView.Uretero‐ileal stricture is a common complication of Bricker urinary diversion in gynecologic cancer, affecting 30% of 77 patients. Preoperative nephrostomy, chronic radiation enteritis, and prior chemotherapy increased the risk, while preoperative ureteral stenting was protective with no effect on overall survival.
Eya Jaafar +14 more
wiley +1 more source