Results 151 to 160 of about 1,106,079 (303)

Ammonia Accumulation Drives Intervertebral Disc Degeneration by Triggering Ammonia‐Induced Cell Death Through Lysosome–Mitochondria Crosstalk

Cell Proliferation, EarlyView.
Mechanical strain disrupts the lysosome‐mitochondria axis via GLS1‐mediated ammonia toxicity, causing NP cell death and ECM breakdown in IVDD. CB839‐mediated GLS1 inhibition effectively rescues cellular homeostasis and alleviates disc degeneration.
Yang Zhang, Yucheng Gao, Shuhang Dong, Shuanggong Liu, Lei Liu, Ziyi Song, Jie Xu, Yijun Rong, Guangxu Song, Yingze Zhang, Dongjin Wu, Zengxin Gao   +11 more
wiley   +1 more source

Shared dysregulation of complement and phosphorylation pathways in the cerebrospinal fluid of encephalitis, Aicardi–Goutières syndrome, and autism

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To identify shared and disorder‐specific molecular alterations across encephalitis, Aicardi–Goutières syndrome (AGS), and autism spectrum disorder (ASD) using cerebrospinal fluid (CSF) proteomics. Method In this cross‐sectional case–control study, mass‐spectrometry‐based proteomics was performed on archived CSF samples collected between ...
Omar H. Shadid, Peter G. Hains, Velda X. Han, Jingya Yan, Michael Griffiths, Ignatius Pang, Sushil Bandodkar, Phillip J. Robinson, Russell C. Dale   +8 more
wiley   +1 more source

Research Review: A scoping review exploring the needs, barriers, and facilitators to the collection of biological data in adolescence for mental health research

Journal of Child Psychology and Psychiatry, EarlyView.
Background There is increasing recognition of the challenge of representativeness in data, including economic, social, and ethnic diversity, in biological mental health research. This is a particular challenge in adolescence, where brain and body development are impacted by the environment.
Courtney Worrell, Camila Ribeiro Perez, Sorcha Alford, Rebecca Pollard, Luca Sforzini, Cole Sommeling, James Hotham, Amanda Rodney, Zara Sadiq, Hana Shah, Tyler Weetman, Gillian Brooks, Matthew R. Broome, Niyah Campbell, Nzinga Gardner, Seeromanie Harding, Anna Lavis, Rosemary R.C. McEachan, Valeria Mondelli, Craig Morgan, Kierra Morris, Chiara Nosarti, Talya Porat, David Ryan, Katy Shire, Anthony Woods, Carmine M. Pariante, CELEBRATE Youth Expert Working Group, Paola Dazzan, Rachel Upthegrove   +29 more
wiley   +1 more source

Predictors of Sacroiliac Joint Intervention Following Lumbar Spine Fusion

Study Design: Retrospective cohort study. Objective: To identify the prevalence and predictors of sacroiliac (SI) joint fusion ...
Raymond J. Hah, Henry Avetisian, Ali Issani, Jeffrey C. Wang, William J. Karakash, Ram K. Alluri, Dil Patel, Matthew Igbinigie, David Riopelle, John C. Liu, Marc Abdou   +10 more
core   +1 more source

Anatomy of spinal CSF loss in the American alligator (Alligator mississippiensis)

Journal of Anatomy, Volume 246, Issue 4, Page 575-584, April 2025.
India ink introduced into the cranial cerebrospinal fluid (CSF) compartment of Alligator diffuses along the spinal cord and exits the spinal compartment using perineural flow, resulting in a prominent “ink cuff” forming at the base of the spinal nerve. In Alligator, the region of the ink cuff is drained by a small lymphatic vessel.
Hadyn DeLeeuw, Michael Cramberg, Matthew Dille, Emily Pick, Mary Thompson, Bruce A. Young   +5 more
wiley   +1 more source

Scrotal pain after lumbar fusion surgery: A rare case report. [PDF]

Medicine (Baltimore)
Cho JH, Bae IS, Kang HI, Kim JH, Jwa C.
europepmc   +1 more source

The effects of bisphosphonates on osteoporotic patients after lumbar fusion: a meta-analysis

, 2018
Wen-bin Liu,1,* Wen-tao Zhao,2,* Peng Shen,3 Fu-jiang Zhang1 1Department of Joint Surgery, Tianjin Hospital, Tianjin 300211, People’s Republic of China; 2Department of Orthopedics, The First Affiliated Hospital of Yunnan Traditional Chinese ...
Zhao WT, Shen P, Zhang FJ, Liu WB
core  

Functional morphology and biomechanics of the locomotor apparatus in the large Late Triassic carnivore Postosuchus kirkpatricki (Archosauria: Rauisuchidae)

Journal of Anatomy, EarlyView.
A three‐dimensional model is used to analyze the locomotor biomechanics of the large Late Triassic archosaurian reptile Postosuchus kirkpatricki. The study finds that it is more uncertain than previously concluded whether it was quadrupedal or bipedal, and plantigrade or digitigrade, but it clearly had locomotor specializations including large hindlimb
John R. Hutchinson, Emily Faughey, Matthew Humpage, Tristan Dupuis, Oliver E. Demuth, Romain Pintore, Francois Clarac   +6 more
wiley   +1 more source

Cumulative effects of lifelong systemic excess growth hormone on postcranial skeletal morphology in adult mice

Journal of Anatomy, EarlyView.
Our μCT‐based pilot study reveals size and shape disparity in the adult postcranial skeleton of growth‐hormone model (bGH) mice relative to wild‐type mice. bGH mice have larger and more sexually dimorphic bones, with a systemic radiodensity increase in bony sesamoids and associated, but typically uncalcified, soft tissues.
Joseph R. Groenke, Huanhuan Liu, Grace Lach, Abhishek Wajpe, Darlene Berryman, John J. Kopchick, Shouan Zhu, Patrick M. O'Connor   +7 more
wiley   +1 more source

Multiscale analysis of the adult human superior hypogastric plexus and hypogastric nerve

Journal of Anatomy, EarlyView.
Using tissue clearing and light‐sheet microscopy methods, we visualized the 3D mesoscopic arrangement of neural tracts, blood vessels and neurons within the adult human superior hypogastric plexus and hypogastric nerves, identifying the latter to contain thousands of neuronal cells bodies embedded along its entire length.
Kayleigh S. Scotcher, John‐Paul Fuller‐Jackson, Peregrine B. Osborne, Martin M. Bertrand, Janet R. Keast   +4 more
wiley   +1 more source