Results 191 to 200 of about 1,106,079 (303)

Synchrony within Aβ mechanoreceptor subtypes governs signal propagation to primary somatosensory cortex

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend We used an optogenetic gain‐of‐function manipulation to investigate how sensory signals from two subtypes of Aβ low threshold mechanoreceptors (LTMRs) contribute to the cortical representation of touch. CatCh, a sensitive and fast channelrhodopsin variant, enables pulsed‐light generation of high‐frequency action potential trains ...
Wanyi Liu   +2 more
wiley   +1 more source

Peripheral regeneration of Aβ low‐threshold mechanoreceptors is limited despite activation of regenerative transcriptional pathways

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The regeneration of Aβ low‐threshold mechanoreceptors (Aβ‐LTMRs), sensory neurons responsible for discriminative touch, has not previously been explored. Here, we took advantage of the selective expression of Calb1 in Aβ‐LTMRs to generate two genetic mouse models for studying their regenerative response after nerve injury.
Sara Bolívar   +3 more
wiley   +1 more source

Haemodynamic and Respiratory Effects of Dexmedetomidine as an Adjuvant to Oxycodone Patient‐Controlled Analgesia After Lumbar Spinal Fusion: A Post Hoc Analysis of the DoseRespDex Randomised Controlled Trial

open access: yesActa Anaesthesiologica Scandinavica, Volume 71, Issue 1, January 2027.
ABSTRACT Purpose Dexmedetomidine has been studied as an adjunct to opioid patient‐controlled analgesia (PCA) because of its opioid‐sparing properties and limited respiratory depression. However, potential dose‐dependent haemodynamic effects should be considered, and data on dexmedetomidine administered via PCA remain limited.
Sanna Mäkelä   +5 more
wiley   +1 more source

Discordance Between Hip-Specific PROMs and Lumbar Symptoms After Total Hip Arthroplasty in Patients With Prior Lumbar Fusion. [PDF]

open access: yesArthroplast Today
Carrier RE   +5 more
europepmc   +1 more source

The Effect of Perioperative Video Interventions on Postoperative Pain Control: A Systematic Review

open access: yesActa Anaesthesiologica Scandinavica, Volume 71, Issue 1, January 2027.
ABSTRACT Introduction Postoperative pain is a major cause of suffering and is linked to serious complications, including delayed wound healing, increased cardiovascular risk, delayed rehabilitation, and chronic postsurgical pain. Modifiable psychological factors influence pain outcomes, and preliminary evidence suggests video interventions can reduce ...
Adam Danielsson   +5 more
wiley   +1 more source

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