Results 81 to 90 of about 173,245 (314)

THBS1+ Macrophages Exacerbate Modic Changes via SDC4‐Dependent Activation of NLRP3 Inflammasome

Advanced Science, EarlyView.
The illustration of THBS1+ macrophages exacerbate MCs via SDC4‐dependent activation of the NLRP3 inflammasome. THBS1+ macrophage subpopulation was identified in MCs through single‐cell RNA sequencing. C. acnes and its metabolites activate THBS1 expression in macrophages via the TLR signaling pathway.
Xiangxi Kong, Qize Xue, Xiaoan Wei, Jie Li, Bao Huang, Weishao Chen, Zimin Cai, Tao Yang, Chengjun Yao, Jiayan Jin, Bohan Cai, Xuyang Zhang, Junhui Liu, Haihao Wu, Jian Chen, Zhi Shan, Fengdong Zhao   +16 more
wiley   +1 more source

Force measurement during spinal mobilisation [PDF]

, 1996
PhDSpinal mobilisation or manipulation techniques are frequently used by physiotherapists in the treatment of musculoskeletal disorders. Despite the reliance on these techniques in clinical practice, there is little scientific evidence to substantiate ...
Harms, Michele C.
core  

Spinal cystic echinococcosis - a systematic analysis and review of the literature : part 1. Epidemiology and anatomy [PDF]

, 2013
Bone involvement in human cystic echinococcosis (CE) is rare, but affects the spine in approximately 50% of cases. Despite significant advances in diagnostic imaging techniques as well as surgical and medical treatment of spinal CE, our basic ...
Goblirsch, Sam, A. Neumayr, Francesca Tamarozzi, Enrico Brunetti (217471), Andreas Neumayr, Brunetti, Enrico, Sam Goblirsch (217453), Brunetti Enrico, Tamarozzi Francesca, Johannes Blum (141240), J. Blum, Neumayr, Andreas, Enrico Brunetti, F. Tamarozzi, Blum Johannes, Johannes Blum, Neumayr Andreas, Andreas Neumayr (198330), Francesca Tamarozzi (217449), Blum, Johannes, Sam Goblirsch, Tamarozzi, Francesca, Goblirsch Sam, S. Goblirsch   +23 more
core   +1 more source

Presentation of an Approach on Determination of the Natural Frequency of Human Lumbar Spine Using Dynamic Finite Element Analysis

Applied Bionics and Biomechanics, 2019
Occurring resonance may negatively affect the health of the human lumbar spine. Hence, vibration generated in working and living environments should be optimized to avoid resonance when identifying the natural frequency of the human lumbar spine.
Fan Ruoxun, Liu Jie, Liu Jun, Wang Weijun   +3 more
doaj   +1 more source

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

Coexisting cervical and lumbar disc degeneration and associated MRI phenotypes: a large-scale population-based study [PDF]

, 2017
Introduction: It remains unknown whether lumbar disc degeneration and patterns therein along with associated lumbar phenotypes (e.g. Modic changes, disc bulge/extrusion) are associated with coexisting cervical degenerative findings on magnetic resonance ...
Luk, KDK, Samartzis, D, Bow, HYC, Cheung, KMC, Karppinen, J   +4 more
core  

Function after spinal treatment, exercise and rehabilitation (FASTER): improving the functional outcome of spinal surgery [PDF]

, 2010
Background: The life-time incidence of low back pain is high and diagnoses of spinal stenosis and disc prolapse are increasing. Consequently, there is a steady rise in surgical interventions for these conditions.
Jamrozik, K., TP Morris, S Morris, Doré CJ, Morris, S, CJ Doré, Morris S, McGregor, A., Doré, C., Morris TP, McGregor, AH, Jamrozik K, Dore, CJ, AH McGregor, Morris, TP, Jamrozik, K, McGregor AH, Morris, S., K Jamrozik, Morris, T.   +19 more
core   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Smart Flexible Tactile Sensors: Recent Progress in Device Designs, Intelligent Algorithms, and Multidisciplinary Applications

Advanced Intelligent Discovery, EarlyView.
Flexible tactile sensors have considerable potential for broad application in healthcare monitoring, human–machine interfaces, and bioinspired robotics. This review explores recent progress in device design, performance optimization, and intelligent applications. It highlights how AI algorithms enhance environmental adaptability and perception accuracy
Siyuan Wang, Ming Dong, Rongrong Bao, Caofeng Pan   +3 more
wiley   +1 more source