Results 281 to 290 of about 92,676 (344)

Jinkyo, a Japanese Traditional (Kampo) Medicine Concept That Is Analogous to Sarcopenia: Its Utility in Daily Practice and Its Physical Background

open access: yesTraditional &Kampo Medicine, Volume 13, Issue 1, April 2026.
ABSTRACT Background Early detection of sarcopenia is important to prevent frailty. In Japanese Traditional (Kampo) medicine (JTM), weakness of the lower abdominal region (WLAR) is considered a sign of the JTM concept jinkyo, which is similar to sarcopenia.
Koichi Ryu   +3 more
wiley   +1 more source

Metastatic Spine Disease Alters Vertebral Load‐To‐Strength Ratios in Cancer Patients Compared to Healthy Individuals

open access: yesJOR SPINE, Volume 9, Issue 1, March 2026.
This study investigated the effect of spinal bone metastasis (BM) on the biomechanical environment of the spine through estimates of load, strength, and the load‐to‐strength ratio (LSR). Our study suggests that task‐specific differences related to cancer, lesion type, and vertebral location differentially affect the biomechanical environment of the ...
Dennis E. Anderson   +13 more
wiley   +1 more source

A feasibility study of functional preservation in craniospinal irradiation with photon for pediatric medulloblastoma

open access: yesJournal of Applied Clinical Medical Physics, Volume 27, Issue 2, February 2026.
Abstract Background Craniospinal irradiation (CSI) is essential for treating pediatric medulloblastoma (MB) but causes significant long‐term toxicities. Existing dose‐reduction or partial‐sparing strategies improve neurocognitive outcomes but may compromise survival or fail to address other late effects.
Keqiang Wang   +5 more
wiley   +1 more source

The Head Circumference Height Index (HCH‐I) to Quantify Relative Macrocephaly and Aid Identification of Hypochondroplasia in Children

open access: yesAmerican Journal of Medical Genetics Part A, Volume 200, Issue 2, Page 353-359, February 2026.
ABSTRACT Hypochondroplasia (HCH) is a rare skeletal dysplasia caused by pathogenic variants in the FGFR3 gene. We hypothesized that the relative disproportion between head circumference and height in HCH might be diagnostically informative and generated a simple index of head‐stature disproportion to help pediatricians diagnose HCH.
Moira S. Cheung   +3 more
wiley   +1 more source

A Confirmatory Case of Severe Spondylocostal Dysostosis Caused by Biallelic Loss‐of‐Function of DMRT2

open access: yesAmerican Journal of Medical Genetics Part A, Volume 200, Issue 2, Page 496-501, February 2026.
ABSTRACT Spondylocostal dysostosis (SCDO) is a rare genetic disorder characterized by abnormal development of the axial skeleton, resulting in malformations of the vertebrae and ribs that often impair lung development and lead to significant respiratory morbidity.
Jonathan Rips   +8 more
wiley   +1 more source

Mitigating subtherapeutic cabozantinib exposure after prior mitotane therapy in adrenocortical carcinoma: Pharmacological boosting with cobicistat

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 606-611, February 2026.
Mitotane is an adrenolytic drug with cytotoxic effects, registered for the treatment of advanced adrenocortical carcinoma (ACC), a rare but aggressive tumour type with a poor prognosis despite treatment. Recently, the oral multi‐kinase inhibitor cabozantinib has shown promising results as a potential second‐line treatment option.
Annemieke M. Peters van Ton   +4 more
wiley   +1 more source

Simultaneous Intracranial and Spinal Hemorrhage Following Tenecteplase Thrombolysis for ST‐Elevation Myocardial Infarction: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Central nervous system (CNS) hemorrhage is a serious complication of intravenous thrombolysis. Tenecteplase, a fibrin‐specific thrombolytic agent, has a lower risk of hemorrhage than other agents. We report the first documented case of simultaneous intracranial and spinal hemorrhage following intravenous administration of tenecteplase.
Thamalee Palliyaguru   +4 more
wiley   +1 more source

Entering a new era for exercise countermeasures in human spaceflight

open access: yes
Experimental Physiology, EarlyView.
Enrico De Martino   +9 more
wiley   +1 more source

Neonatal Arnold–Chiari II Malformation: An Imaging‐Focused Case Report

open access: yesClinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Arnold‐Chiari Malformation Type II (CM‐II) is a serious congenital hindbrain disorder marked by the displacement of the cerebellum and brainstem downwards through the foramen magnum. CM‐II is frequently linked with myelomeningocele and hydrocephalus.
Mohammad Alashqar   +8 more
wiley   +1 more source

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