Results 191 to 200 of about 77,522 (264)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Smart Semiconductors: An Overview of AZnOS (A= Ca, Sr, Ba) Based Phosphors, Multi-Stimuli Responsive Luminescence, and Potential Application Prospects. [PDF]

Adv Sci (Weinh)
Wang Y, Zhang X, Ren B, Zhang J, Zhang Q, Fang Z, Wu M, Li L, Yang Y, Zhuang Y, Bai G, Gan J, Peng D.   +12 more
europepmc   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Luminescent Fe₃O₄ Nanohybrid for Intra-Cellular Imaging and Combinatorial Chemo-Photothermal Therapy in Cancer. [PDF]

Chembiochem
Dutta B, Gupta S, Purandare S, Bind P, Bapat R, Prasad NK, Barick KC, Hassan PA.   +7 more
europepmc   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Rapid Quantification of Bluetongue Virus-Neutralizing Antibodies Using Bioluminescent Reporter-Expressing Viruses. [PDF]

Vaccines (Basel)
Jiménez-Cabello L, Utrilla-Trigo S, Calvo-Pinilla E, Nogales A, Ortego J.   +4 more
europepmc   +1 more source

Mechanism of the Photodecomposition of Stable Triarylmethyl Radicals. [PDF]

Angew Chem Int Ed Engl
Hackney HE, Legault CY, Titi HM, Perepichka DF.   +3 more
europepmc   +1 more source

sgRNA amount is a limiting factor in adenine base editing using RNA LNPs. [PDF]

Mol Ther Nucleic Acids
Birkenshaw A, Thomson T, Truong MP, Komaki Y, Ramsden N, Timpano A, Huang C, Blakney AK, Kurek DZ, Kulkarni J, Ross CJD.   +10 more
europepmc   +1 more source

High-Quantum-Yield [Eu(Phen)₂(NO₃)₃] Phosphor Exhibiting Zero Thermal Quenching under Real Operating Conditions (30-150 °C). [PDF]

ACS Omega
Raymundo Silva KS, Salas Juárez CJ, Guzmán Silva RE, Garduño Wilches IA, Beltrán Conde HI, Guzmán Mendoza J.   +5 more
europepmc   +1 more source

Intermolecular Organization of a Lyotropic Liquid Crystal and Carbon Dot Composite in Microfluidic Channels: Surface and Dynamic Effects. [PDF]

Nanomaterials (Basel)
Bezrukov A, Galeeva A, Krupin A, Galyametdinov Y.   +3 more
europepmc   +1 more source