Results 41 to 50 of about 135,105 (302)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Site-selective ser-hydrolase labelling with a luminescent organometallic NCN-platinum complex [PDF]

, 2010
The synthesis, spectroscopic properties and protein-binding studies of a novel luminescent organometallic NCN-platinum complex are described. The luminescent organometallic complex was linked to a serine hydrolase reactive phosphonate group by means of ...
van Koten, G., Sub Chem Biol & Organic Chem begr 1-6-12, Organic Chemistry and Catalysis, Dijkstra, H.P., Sub Membrane Enzymology begr. 01-06-12, Egmond, M.R., Lemcke, B., Klein Gebbink, R.J.M., Dep Scheikunde, Wieczorek, B., Membrane Enzymology   +10 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Axial InN/InGaN Nanorod Array Heterojunction Photodetector with Ultrafast Speed

Advanced Electronic Materials, 2023
Due to wavelength‐selective characteristics, the InGaN‐based photodetectors show bright prospects in visible light communication and fast imaging system.
Jixing Chai, Qianhu Liu, Liang Chen, Ben Cao, Deqi Kong, Tingjun Lin, Wenliang Wang, Guoqiang Li   +7 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Creative use of BIPV materials: barriers and solutions [PDF]

, 2012
Inventive use of photovoltaic (PV) materials in architecture can be developed through use of PV in artworks. This is particularly important in increasing the uptake of building-integrated building-integrated photovoltaics (BIPV), by developing ...
Hardy, DA, Kerrouche, A, Roaf, SC, Blekastad, S, Richards, BS   +4 more
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Synthesis and characterization of time-resolved lanthanide (III) luminescent probes for potential detection of melanoma skin cancer [PDF]

, 2017
The focal point of this research is to continue the development of a time-resolved lanthanide (III) luminescent probe that may aid in early detection of melanoma skin cancer. If melanoma cancer is found at an early stage, it can successfully be taken out
NC DOCKS at Western Carolina University, Love, Brian William   +1 more
core  

Luminescent Au6 and Au8 nanoclusters from ligand induced etching of Au nanoparticles

Materials Research Express, 2019
Metal nanoclusters (NCs) with atomic precision are receiving significant attention because of their widespread applications in the field of energy-related materials, sensing and biomedicine. In this work, luminescent Au nanoclusters (NCs) are synthesized
Dipankar Bain, Subarna Maity, Tanay Debnath, Abhijit Kumar Das, Amitava Patra   +4 more
doaj   +1 more source

A theoretical study of thermal management of FBAR considering thickness- and temperature-dependent thermal conductivity of AlN

AIP Advances, 2022
Reliable and long-term operation of thin film bulk acoustic resonators (FBARs) under high power relies on the optimization of thermal resistance. In this work, thermal design strategies for high power FBARs are explored theoretically.
Lishuai Zhao, Xinyan Yi, Peidong Ouyang, Guoqiang Li   +3 more
doaj   +1 more source