Results 41 to 50 of about 122,223 (316)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
IEEE Journal of the Electron Devices Society, 2021 A modified NMOS inverter employing output feedback theme has been proposed in this paper. The feedback structure can guarantee high voltage output at a wider range of low voltage input.
Pei-An Zou +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Luminescent Au6 and Au8 nanoclusters from ligand induced etching of Au nanoparticles
Materials Research Express, 2019 Metal nanoclusters (NCs) with atomic precision are receiving significant attention because of their widespread applications in the field of energy-related materials, sensing and biomedicine. In this work, luminescent Au nanoclusters (NCs) are synthesized
Dipankar Bain +4 more
doaj +1 more source
Stretchable transparent electrodes for conformable wearable organic photovoltaic devices
npj Flexible Electronics, 2021 To achieve adhesive and conformable wearable electronics, improving stretchable transparent electrode (STE) becomes an indispensable bottleneck needed to be addressed.
Nan Cui +7 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Synthesis and characterization of time-resolved lanthanide (III) luminescent probes for potential detection of melanoma skin cancer [PDF]
, 2017 The focal point of this research is to continue the development of a time-resolved lanthanide (III) luminescent probe that may aid in early detection of melanoma skin cancer. If melanoma cancer is found at an early stage, it can successfully be taken out
NC DOCKS at Western Carolina University +1 more
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
, 2015 The design and synthesis of a number of luminescent transition metal complexes will be described, and their rich photophysical properties will be examined.
Yam, VWW, Yeung, MCL
core +1 more source