Results 41 to 50 of about 32,712 (291)

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

Ecological anatomy of Eugenia punicifolia (Kunth) DC. (MYRTACEAE) in the restinga region,state of Ceará [PDF]

Revista Brasileira de Fruticultura, 2019
The species Eugenia punicifolia (Kunth) DC. (myrtle) occurs in the coastal region of the state of Ceará and has ecological and medicinal importance. This study aimed to characterize the leaf anatomy of myrtle (E. punicifolia) in the rainy and dry seasons,
Viviane de Oliveira Thomaz Lemos, Eliseu Marlônio Pereira de Lucena, Oriel Herrera Bonilla, Bruno Edson-Chaves   +3 more
doaj   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Luminosity Measurements at the LHC at CERN Using Medipix, Timepix and Timepix3 Devices

Physics, 2021
The precise determination of the luminosity is essential for many analyses in physics based on the data from the particle accelerator Large Hadron Collider (LHC) at CERN. There are different types of detectors used for the luminosity measurements.
André Sopczak
doaj   +1 more source

The bolometric luminosities of stars [PDF]

Symposium - International Astronomical Union, 1997
The total energy emitted by a star is one of its basic parameters. It is also one of the most difficult to determine, requiring space-based as well as ground-based measurements of the absolute flux from stars. We review the current status of these observations in the ultraviolet, visible, and near infrared, and estimate the uncertainties of the ...
Jeffrey W. Percival, Robert Bless
openaire   +3 more sources

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source

K-corrections: an Examination of their Contribution to the Uncertainty of Luminosity Measurements

The Open Journal of Astrophysics, 2016
In this paper we provide formulae that can be used to determine the uncertainty contributed to a measurement by a K-correction and, thus, valuable information about which flux measurement will provide the most accurate K-corrected luminosity. All of this
Sean Lake, Ned Wright
doaj   +1 more source

Influence of Mineral Particle Films and Biomaterials on Guava Fruits and Implications for the Oviposition of Anastrepha obliqua (Macquart) (Diptera: Tephritidae)

Insects, 2021
Anastrepha obliqua (Macquart, 1835) is an important pest of tropical fruits, especially Anacardiaceae and Myrtaceae, in the Americas. The objective of this study was to evaluate the influence of mineral films and biomaterials on the coloring of guava ...
Daniela Ribeiro da Costa, Suzany Aguiar Leite, Mateus Pereira dos Santos, Beatriz Sousa Coelho, Aldenise Alves Moreira, Carlos Alberto Domingues da Silva, Iara Sordi Joachim-Bravo, Maria Aparecida Castellani   +7 more
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source