Results 41 to 50 of about 172,037 (253)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
The use of biostimulants has been studied as a technology that improves the cultivation of plant species and could therefore be an option for producing turfgrass seedlings.
Beatriz Watanabe +7 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
A buva (Conyza canadensis e C. bonariensis) é uma planta daninha de importância crescente no Brasil. Essas espécies ocorrem em diversas regiões do mundo, sendo importantes infestantes de culturas perenes e anuais sob sistema de semeadura direta, cultivo ...
O.M. Yamashita, S.C. Guimarães
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
The establishment of the luminosity function for brown dwarf candidates in GAIA Early Data Release 3
Gizis, John E.Brown dwarfs are classified as objects with masses between that of stars and planets. First theorized in the 1960s, they remained an elusive target for detection until the mid 1990s since they have no sustainable energy source therefore ...
Hilligoss, Dylan M.
core +1 more source
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Luminosity-metallicity relation for stars on the lower main sequence
We present a comparison of the predictions of stellar models with the luminosity of the lower main sequence ($5.5 < M_V < 7.3$) using K dwarfs in the Hipparcos catalog. The parallaxes of our comparison stars are known to better than 15% and metallicities
Christopher Flynn (18926074) +2 more
core +1 more source
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source

