Results 41 to 50 of about 14,265 (223)
The Notch signaling pathway plays a dual role in cancer, acting as both a tumor promoter and suppressor depending on cellular context. This review highlights how natural products modulate Notch signaling to inhibit tumor initiation, progression, angiogenesis, and cancer stem cell maintenance.
Rabab Fatima +15 more
wiley +1 more source
Abstract Public opinion polling has found that responses to the second presidency of Donald Trump range from the exuberant enthusiasm of his followers to anxiety, stress and anger, not only amongst many US citizens, but also a large section of the world's population who did not vote for him but are affected by his policies and governing style.
STEPHEN COLEMAN
wiley +1 more source
Faithful men and false women: Love‐suicide in early modern English popular print
Abstract This article explores the representation of suicide committed for love in English popular print in the seventeenth and early eighteenth centuries. It shows how, within ballads and pamphlets, suicide resulting from failed courtship was often portrayed as romantic and an expression of devotion.
Imogen Knox
wiley +1 more source
Notch signaling receptors, ligands, and their downstream target genes are dysregulated in pancreatic ductal adenocarcinoma (PDAC), suggesting a role of Notch signaling in pancreatic tumor development and progression.
Rashu Barua +6 more
doaj +1 more source
Disability, Gender and Segregation in the Britain–Australia Convict System
ABSTRACT This article assesses the gendered experiences of disability and segregation among prisoners in colonial (1830s) New South Wales. I use the distinction between impairment and disability from the ‘social model of disability’ to show that the disabling capacities of impairments varied depending on wider social structures and beliefs, and on each
Emily Cock
wiley +1 more source
“Ridiculous Charlatans or Lunatic Neck Cutters”: Image of Spiritism in Republican Brazil
With the ultimate triumph of liberal Republicanism in 1889 in Brazil and the adoption of a constitution promoting the separation of Church and State, the formerly dominant Roman Catholic Church entered a long period of struggle to recover its lost ...
František Kalenda
doaj +1 more source
From “Modern Midas Mineral” to “Satanic Substance”: Uranium, Unions, and the Atomic Age
Uranium mining and export was a major flashpoint for political debate in 1970's Australia. However, there has been relatively little investigation into how uranium was understood and contested before this time. This paper draws on labour movement publications and other archival sources to reveal lesser‐known antecedents to the anti‐uranium movement in ...
Nicholas Herriot
wiley +1 more source
Women’s mental healthcare in the Republic of Ireland
This paper describes recent developments in mental healthcare for women in Ireland and sets them in their historical context. The treatment of women’s mental health in the Republic of Ireland has evolved drastically since the 19th century, when ...
Yvonne Hartnett +2 more
doaj +1 more source
Liberalism as a Way of Political Life: The Case of George Brandis
The lawyer, politician, and diplomat George Brandis was the leading intellectual representative of moderate or “small‐l” liberalism in the contemporary Liberal Party. He criticised John Howard for an ad hoc balancing of liberalism and conservatism. Brandis believed the Liberal Party necessarily included conservatives, but to him their role was to be a ...
Geoffrey Robinson
wiley +1 more source

