Results 41 to 50 of about 14,265 (223)

Natural Products Targeting Notch Signaling in Cancer: Mechanistic Insights and Food‐Based Chemoprevention Potential

open access: yesFood Frontiers, EarlyView.
The Notch signaling pathway plays a dual role in cancer, acting as both a tumor promoter and suppressor depending on cellular context. This review highlights how natural products modulate Notch signaling to inhibit tumor initiation, progression, angiogenesis, and cancer stem cell maintenance.
Rabab Fatima   +15 more
wiley   +1 more source

How Trump Gets on Our Nerves

open access: yesThe Political Quarterly, EarlyView.
Abstract Public opinion polling has found that responses to the second presidency of Donald Trump range from the exuberant enthusiasm of his followers to anxiety, stress and anger, not only amongst many US citizens, but also a large section of the world's population who did not vote for him but are affected by his policies and governing style.
STEPHEN COLEMAN
wiley   +1 more source

Faithful men and false women: Love‐suicide in early modern English popular print

open access: yesGender &History, EarlyView.
Abstract This article explores the representation of suicide committed for love in English popular print in the seventeenth and early eighteenth centuries. It shows how, within ballads and pamphlets, suicide resulting from failed courtship was often portrayed as romantic and an expression of devotion.
Imogen Knox
wiley   +1 more source

Bioinformatics and Functional Analyses Implicate Potential Roles for EOGT and L-fringe in Pancreatic Cancers

open access: yesMolecules, 2021
Notch signaling receptors, ligands, and their downstream target genes are dysregulated in pancreatic ductal adenocarcinoma (PDAC), suggesting a role of Notch signaling in pancreatic tumor development and progression.
Rashu Barua   +6 more
doaj   +1 more source

PAUPER LUNATICS. [PDF]

open access: yesThe Lancet
n ...
openaire   +1 more source

Disability, Gender and Segregation in the Britain–Australia Convict System

open access: yesGender &History, EarlyView.
ABSTRACT This article assesses the gendered experiences of disability and segregation among prisoners in colonial (1830s) New South Wales. I use the distinction between impairment and disability from the ‘social model of disability’ to show that the disabling capacities of impairments varied depending on wider social structures and beliefs, and on each
Emily Cock
wiley   +1 more source

“Ridiculous Charlatans or Lunatic Neck Cutters”: Image of Spiritism in Republican Brazil

open access: yesIbero-Americana Pragensia, 2018
With the ultimate triumph of liberal Republicanism in 1889 in Brazil and the adoption of a constitution promoting the separation of Church and State, the formerly dominant Roman Catholic Church entered a long period of struggle to recover its lost ...
František Kalenda
doaj   +1 more source

From “Modern Midas Mineral” to “Satanic Substance”: Uranium, Unions, and the Atomic Age

open access: yesAustralian Journal of Politics &History, EarlyView.
Uranium mining and export was a major flashpoint for political debate in 1970's Australia. However, there has been relatively little investigation into how uranium was understood and contested before this time. This paper draws on labour movement publications and other archival sources to reveal lesser‐known antecedents to the anti‐uranium movement in ...
Nicholas Herriot
wiley   +1 more source

Women’s mental healthcare in the Republic of Ireland

open access: yesBJPsych International
This paper describes recent developments in mental healthcare for women in Ireland and sets them in their historical context. The treatment of women’s mental health in the Republic of Ireland has evolved drastically since the 19th century, when ...
Yvonne Hartnett   +2 more
doaj   +1 more source

Liberalism as a Way of Political Life: The Case of George Brandis

open access: yesAustralian Journal of Politics &History, EarlyView.
The lawyer, politician, and diplomat George Brandis was the leading intellectual representative of moderate or “small‐l” liberalism in the contemporary Liberal Party. He criticised John Howard for an ad hoc balancing of liberalism and conservatism. Brandis believed the Liberal Party necessarily included conservatives, but to him their role was to be a ...
Geoffrey Robinson
wiley   +1 more source

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