Results 171 to 180 of about 4,776,663 (339)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

A case of mucous gland adenoma of lung: a benign mimicker of malignancy

Journal of Current Oncology and Medical Sciences
Introduction: Mucous gland adenoma of the lung (MGA) is an uncommon benign tumor. MGA of lung is extremely rare with less than 70 cases documented in the literature to the best of our knowledge.
Veeksha Venugopal Gowda , Divya Vijayanarasimha , Rekha Vijay Kumar , Sanjeev Kulkarni   +3 more
doaj  

Evaluating the impact of deep learning-based image denoising on low-dose CT for lung cancer screening. [PDF]

J Appl Clin Med Phys
Chen SS, Liu HH, Yang CC.
europepmc   +1 more source

Lung maturation [PDF]

Proceedings of the Nutrition Society, 1996
R, Hume, C, Conner, M, Gilmour
openaire   +2 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Correlation between lung ultrasound B lines and clinical as well as echocardiographic parameters in patients on maintenance hemodialysis. [PDF]

Sci Rep
Shah MK, Patel RD, Patel RJ, Mannari JG, Makwana M, Kute V, Ganjiwale J.   +6 more
europepmc   +1 more source

Evaluation of the 3‐minute chair rise test as part of preoperative evaluation for patients with non‐small cell lung cancer

, 2020
Mathilde Azzi, David Debeaumont, Tristan Bonnevie, B. Aguilaniu, Damiano Cerasuolo, Fairuz Boujibar, A. Cuvelier, Francis‐Edouard Gravier   +7 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Steerable Needle Trajectory Following in the Lung: Torsional Deadband Compensation and Full Pose Estimation With 5DOF Feedback for Needles Passing Through Flexible Endoscopes

, 2020
Tayfun Efe Ertop, Maxwell Emerson, Margaret Rox, Josephine Granna, Robert J. Webster, Fabien Maldonado, Erin A. Gillaspie, Michael Lester, Alan Kuntz, D. Caleb Rucker, Mengyu Fu, Janine Hoelscher, Inbar Fried, Ron Alterovitz   +13 more
openalex   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source