Results 21 to 30 of about 2,198,200 (198)

International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma

Journal of Thoracic Oncology, 2011
Introduction: Adenocarcinoma is the most common histologic type of lung cancer. To address advances in oncology, molecular biology, pathology, radiology, and surgery of lung adenocarcinoma, an international multidisciplinary classification was sponsored ...
W. Travis, E. Brambilla, M. Noguchi, A. Nicholson, K. Geisinger, Y. Yatabe, D. Beer, C. Powell, Gregory Riely, P. V. Van Schil, K. Garg, J. Austin, H. Asamura, V. Rusch, F. Hirsch, G. Scagliotti, T. Mitsudomi, R. Huber, Y. Ishikawa, J. Jett, M. Sanchez-Cespedes, J. Sculier, Takashi Takahashi, M. Tsuboi, J. Vansteenkiste, I. Wistuba, Pan‐Chyr Yang, D. Aberle, C. Brambilla, D. Flieder, W. Franklin, A. Gazdar, M. Gould, P. Hasleton, D. Henderson, B. Johnson, David H. Johnson, K. Kerr, K. Kuriyama, J. S. Lee, V. Miller, I. Petersen, V. Roggli, R. Rosell, N. Saijo, E. Thunnissen, M. Tsao, David Yankelewitz   +47 more
semanticscholar   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Lung cancer.

Cancer chemotherapy and biological response modifiers, 1990
Lung cancer was the leading cause of cancer deaths in North Carolina in 2012 (29.6%). It has been the leading cause of cancer deaths in North Carolina for over two decades. It was estimated that 8,624 people in North Carolina would be diagnosed with lung
H. Hansen, M. Ro̸rth
semanticscholar   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification.

Journal of Thoracic Oncology, 2015
The 2015 World Health Organization (WHO) Classification of Tumors of the Lung, Pleura, Thymus and Heart has just been published with numerous important changes from the 2004 WHO classification. The most significant changes in this edition involve (1) use
W. Travis, E. Brambilla, A. Nicholson, Y. Yatabe, J. Austin, M. Beasley, L. Chirieac, S. Dacic, E. Duhig, D. Flieder, K. Geisinger, F. Hirsch, Y. Ishikawa, K. Kerr, M. Noguchi, G. Pelosi, C. Powell, M. Tsao, I. Wistuba   +18 more
semanticscholar   +1 more source

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

FEBS Letters, EarlyView.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine, Matteo Mucci, Antonio Recchiuti, Domenico Mattoscio   +3 more
wiley   +1 more source

Erlotinib in previously treated non-small-cell lung cancer.

New England Journal of Medicine, 2005
BACKGROUND We conducted a randomized, placebo-controlled, double-blind trial to determine whether the epidermal growth factor receptor inhibitor erlotinib prolongs survival in non-small-cell lung cancer after the failure of first-line or second-line ...
F. Shepherd, J. Rodrigues Pereira, T. Ciuleanu, E. Tan, V. Hirsh, S. Thongprasert, D. Campos, Savitree Maoleekoonpiroj, M. Smylie, R. Martins, M. van Kooten, M. Dediu, B. Findlay, D. Tu, D. Johnston, A. Bezjak, G. Clark, P. Santabarbara, L. Seymour   +18 more
semanticscholar   +1 more source

Screening for Lung Cancer: US Preventive Services Task Force Recommendation Statement.

Journal of the American Medical Association (JAMA), 2021
Importance Lung cancer is the second most common cancer and the leading cause of cancer death in the US. In 2020, an estimated 228 820 persons were diagnosed with lung cancer, and 135 720 persons died of the disease.
A. Krist, K. Davidson, C. Mangione, M. Barry, M. Cabana, A. Caughey, E. Davis, Katrina E. Donahue, Chyke A Doubeni, Martha Y. Kubik, C. Landefeld, Li Li, G. Ogedegbe, D. Owens, L. Pbert, Michael Silverstein, J. Stevermer, Chien-Wen Tseng, J. Wong   +18 more
semanticscholar   +1 more source

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

FEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva, Marcio Vinicius Bertacine Dias   +1 more
wiley   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source