Results 71 to 80 of about 924,560 (254)

Expression of ASPM in Lung Adenocarcinoma and Its Relationship with Development and Prognosis

Chinese Journal of Lung Cancer, 2020
Background and objective Previous studies have shown that ASPM is a tumorigenesis associated protein, mutations in ASPM can lead to MCPH. This study mainly explores the relationship between the ASPM expression of lung adenocarcinoma and the development ...
Junjie WANG, Zhenyu HE, Renhui DUAN
doaj   +1 more source

MEK5 promotes lung adenocarcinoma [PDF]

European Respiratory Journal, 2018
MEK5 acts as an oncogenic driver in mice lung cancer and is pivotal for human lung adenocarcinoma http://ow.ly ...
Sánchez Fernández, Adrián, Ortíz Ruíz, María Jesús, Re-Louhau, María Florencia, Ramos, Isabel, Blanco-Múñez, Óscar, Ludeña de la Cruz, María Dolores, Abad Hernández, María Mar, Sánchez Martín, Manuel Adolfo, Pandiella Alonso, Atanasio, Esparís Ogando, Azucena   +9 more
openaire   +3 more sources

Adenocarcinoma of the lung mimicking interstitial lung disease

Atypical radiologic and clinical patterns may be observed within subgroups of lung adenocarcinoma. A 74-year-old man with progressive dyspnea and productive cough unresponsive to antibiotherapy showed bilateral interstitial changes in the lung parenchyma
Baysal, Tamer, Sümeyye Kodalak Cengiz, Nesrin Kıral, Cengiz, SÜMEYYE, Geçmen, Gonca Gül, Tamer Baysal, Gonca Gül Geçmen, Kıral, Nesrin   +7 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Expression and clinical role of in lung adenocarcinoma

Journal of International Medical Research
Objective To explore the levels of expression and clinical role of peroxiredoxin 6 ( PRDX6 ) in lung adenocarcinoma. Methods This retrospective study used a series of bioinformatics methods to detect the levels of expression of and mutations in the PRDX6
Zixin Chen, Junjun Lin, Huifang Wang, Jing Wang, Zhou Zhang   +4 more
doaj   +1 more source

Tiptoeing on Metastatic Adenocarcinoma of the Lung [PDF]

Case Reports in Oncological Medicine, 2019
Lung cancer remains the top cause of cancer-related death in the United States. Metastases to the distal phalanges are rare. This case illustrates an interesting presentation of metastatic adenocarcinoma of the lung that was mistaken for a benign condition of the toe.
Arupreet Kochar, Harrison D. Winters, Li Zhang, Bin Zhang, Kamia Thakur, Rajesh Essrani   +5 more
openaire   +3 more sources

Predilection of contralateral upper lung metastasis in upper lobe lung adenocarcinoma patients

, 2017
Background: Lung cancer with lung to lung metastasis is common. The objective of this study was to investigate the association among the distribution of contralateral lung metastases versus primary lung tumor location, clinical characteristics, and ...
Huang, Yen-Hsiang;Hsu, Kuo-Hsuan;Tseng, Jeng-Sen;Chen, Kun-Chieh;Su, Kang-Yi;Chen, Hsuan-Yu;Chang, Chi-Sheng;Chen, Jeremy J. W.;Yu, Sung-Liang;Chen, Huei-Wen;Yang, Tsung-Ying;Chang, Gee-Chen, 俞松良;蘇剛毅;陳惠文   +1 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Impact of histopathological subtypes on invasive lung adenocarcinoma: from epidemiology to tumour microenvironment to therapeutic strategies

World Journal of Surgical Oncology
Lung adenocarcinoma is the most prevalent type of lung cancer, with invasive lung adenocarcinoma being the most common subtype. Screening and early treatment of high-risk individuals have improved survival; however, significant differences in prognosis ...
Shaowei Xin, Miaomiao Wen, Yahui Tian, Honghong Dong, Zitong Wan, Suxin Jiang, Fancheng Meng, Yanlu Xiong, Yong Han   +8 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source