Results 191 to 200 of about 5,690,964 (274)
A potential tumor suppressor role of PLK2 in glioblastoma
FEBS Open Bio, EarlyView.PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...Xiangping Xia, Peirui Wang, Hua Xiao, Qishan Ran, Yan Li, Shengtao Yao +5 morewiley +1 more sourceHydrophobicity causes anomalous migration of cystine/glutamate antiporter SLC7A11 in SDS‐PAGE with low acrylamide concentration
FEBS Open Bio, EarlyView.SLC7A11 frequently migrates faster in SDS‐PAGE. The present study found that the high hydrophobicity of SLC7A11 causes its anomalous migration in SDS‐PAGE with a low concentration of acrylamide gel. Replacing isoleucine with asparagine reduced hydrophobicity and restored its normal migration at 55 kDa, revealing the role of hydrophobicity and gel ...Nsengiyumva Emmanuel, Qian He, Yixin Kang, Dianbao Zhang, Min Gao, Minglin Wang, Kexin Fan, Jingwen Xiong, Shaobo Wu, Botao Fa, Zhengtao Xiao, Yingfang Niu, Jun Yao, Yilei Zhang +13 morewiley +1 more sourceThe IASLC Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Lung Cancer
Journal of Thoracic Oncology, 2016 P. Goldstraw, K. Chansky, J. Crowley, R. Rami-Porta, H. Asamura, W. Eberhardt, A. Nicholson, P. Groome, A. Mitchell, V. Bolejack, R. Rami-Porta, D. Ball, D. Beer, R. Beyruti, F. Detterbeck, Wilfried Ernst Erich Eberhardt, J. Edwards, F. Galateau-Salle, D. Giroux, F. Gleeson, James Huang, C. Kennedy, Jhingook Kim, Y. T. Kim, L. Kingsbury, H. Kondo, M. Krasnik, K. Kubota, A. Lerut, G. Lyons, M. Marino, E. Marom, J. V. van Meerbeeck, T. Nakano, A. Nowak, M. Peake, T. Rice, K. Rosenzweig, E. Ruffini, V. Rusch, N. Saijo, P. V. Van Schil, J. Sculier, L. Shemanski, K. Stratton, Kenji Suzuki, Y. Tachimori, C. Thomas, W. Travis, M. Tsao, A. Turrisi, J. Vansteenkiste, Hirokazu Watanabe, Yi‐Long Wu, P. Baas, J. Erasmus, S. Hasegawa, K. Inai, K. Kernstine, H. Kindler, L. Krug, K. Nackaerts, H. Pass, D. Rice, C. Falkson, P. Filosso, G. Giaccone, K. Kondo, M. Lucchi, M. Okumura, E. Blackstone, A. Cavaco, A. Barrera, Abal J. Arca, Parente I. Lamelas, Arnau A. Obrer, Guijarro R. Jorge, D. Ball, G. Bascom, B. Orozco, González M.A. Castro, M. Blum, D. Chimondeguy, V. Cvijanović, S. Defranchi, B. de Olaiz Navarro, Escobar I. Campuzano, Macía I. Vidueira, F. E. Araujo, André F. Garcia, K. Fong, Francisco G. Corral, C. S. Gonzalez, Freixinet J. Gilart, García L. Arangüena, García S. Barajas, P. Girard, T. Goksel, González M.T. Budiño, González G. Casaurrán, Gullón J.A. Blanco, Hernández J. Hernández, Hernández H. Rodríguez, Herrero J. Collantes, Iglesias M. Heras, Izquierdo J.M. Elena, E. Jakobsen, S. Kostas, León P. Atance, Núñez A. Ares, M. Liao, M. Losanovscky, G. Lyons, R. Magaroles, L. de Esteban Júlvez, Mariñán M. Gorospe, B. McCaughan, C. Kennedy, M. R. Íñiguez, Miravet L. Sorribes, Naranjo S. Gozalo, Álvarez C. de Arriba, Núñez M. Delgado, Padilla J. Alarcón, Peñalver J.C. Cuesta, J. Park, H. Pass, Pavón M.J. Fernández, M. Rosenberg, E. Ruffini, V. Rusch, Sánchez J. de Cos Escuín, Saura A. Vinuesa, Serra M. Mitjans, T. Strand, D. Subotic, S. Swisher, R. Terra, C. Thomas, K. Tournoy, P. V. Van Schil, M. Velasquez, Y. Wu, K. Yokoi +143 moresemanticscholar +1 more sourceComparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer
FEBS Open Bio, EarlyView.We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh +9 morewiley +1 more sourceAdenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study
FEBS Open Bio, EarlyView.The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori +15 morewiley +1 more source