Results 151 to 160 of about 1,756,909 (330)

Quantification and characterization of lung fibrosis in ARDS patients using picrosirius red staining

Frontiers in Medicine
IntroductionEvolution toward diffuse lung fibrosis is common in patients with ARDS but remains poorly characterized. In particular, the quantification and characterization of collagen fibers in lung tissue from patients with ARDS has not been performed ...
Ludovic Gerard, Ludovic Gerard, Marylene Lecocq, Guillaume Courtoy, Guillaume Courtoy, Caroline Bouzin, Delphine Hoton, Joao Pinto Pereira, Joao Pinto Pereira, Thomas Planté-Bordeneuve, Thomas Planté-Bordeneuve, Antoine Froidure, Antoine Froidure, Valérie Lacroix, Valérie Lacroix, Charles Pilette, Charles Pilette   +16 more
doaj   +1 more source

Inhalation potential of N-Acetylcysteine loaded PLGA nanoparticles for the management of tuberculosis: In vitro lung deposition and efficacy studies. [PDF]

Curr Res Pharmacol Drug Discov, 2022
Puri V, Chaudhary KR, Singh A, Singh C.
europepmc   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Dual targeting powder formulation of antiviral agent for customizable nasal and lung deposition profile through single intranasal administration. [PDF]

Int J Pharm, 2022
Seow HC, Liao Q, Lau ATY, Leung SWS, Yuan S, Lam JKW.   +5 more
europepmc   +1 more source

Calculation of hygroscopic particle deposition in the human lung.

, 2014
Context: Inhaled hygroscopic aerosols will absorb water vapor from the warm and humid air of the human lung, thus growing in size and consequently changing their deposition properties.
Ferron, G.A., Winkler-Heil, R., Hofmann, W.   +2 more
core   +1 more source

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

Validated respiratory drug deposition predictions from 2D and 3D medical images with statistical shape models and convolutional neural networks.

PLoS ONE
For the one billion sufferers of respiratory disease, managing their disease with inhalers crucially influences their quality of life. Generic treatment plans could be improved with the aid of computational models that account for patient-specific ...
Josh Williams, Haavard Ahlqvist, Alexander Cunningham, Andrew Kirby, Ira Katz, John Fleming, Joy Conway, Steve Cunningham, Ali Ozel, Uwe Wolfram   +9 more
doaj   +1 more source

Lung Deposition of Inhaled Extrafine Beclomethasone Dipropionate/Formoterol Fumarate/Glycopyrronium Bromide in Healthy Volunteers and Asthma: The STORM Study. [PDF]

J Aerosol Med Pulm Drug Deliv, 2022
Usmani OS, Baldi S, Warren S, Panni I, Girardello L, Rony F, Taylor G, DeBacker W, Georges G.   +8 more
europepmc   +1 more source

Biofilm‐Binding Phages Enhance Biofilm Eradication by Synergistic Photothermal and Photodynamic Therapy

Advanced Science, EarlyView.
Engineered phage‐based trifunctional nanofibers are developed for synergistic biofilm eradication. Biofilm‐binding phages, armed with AuNPs and TCPP, serve as both warheads and scaffolds, endowing the phototherapy agents with biofilm‐anchoring ability. Upon light irradiation, AuNPs induce photothermal therapy, while TCPP generates 1O2 for photodynamic ...
Ying Cao, Tao Yang, Rui Wang, Hui‐Da Li, Xiao‐Yu Zhang, Feng Cheng, Ying Liu, Jian‐Hua Wang, Ting Yang, Chuanbin Mao   +9 more
wiley   +1 more source

Estimating Lung Deposition of Fungal Spores Using Actual Airborne Spore Concentrations and Physiological Data. [PDF]

Environ Sci Technol, 2021
Secondo LE, Sagona JA, Calderón L, Wang Z, Plotnik D, Senick J, Sorensen-Allacci M, Wener R, Andrews CJ, Mainelis G.   +9 more
europepmc   +1 more source