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Notch in lung development and lung cancer
Seminars in Cancer Biology, 2004Although data regarding the role of the Notch pathway in human lung cancer are still limited, fetal lung developmental studies suggest that Notch signaling plays a critical role in regulating airway epithelial development. The moderate hypotrophic phenotype of lungs from animals bearing a Hes1 mutation, and the expression of Notch components in the ...
Brendan J, Collins +2 more
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Lung Development and Adult Lung Diseases
Chest, 2007Adult respiratory diseases are caused by many factors, including genetic-environmental interaction. Genetic abnormalities can impact early fetal lung development, postnatal lung maturation, as well as adult lung injury and repair. Studies suggest that abnormally developed lung structure and function may contribute as a susceptibility factor for several
Wei, Shi +2 more
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Early Human Development, 2007
Human lung growth starts as a primitive lung bud in early embryonic life and undergoes several morphological stages which continue into postnatal life. Each stage of lung growth is a result of complex and tightly regulated events governed by physical, environmental, hormonal and genetic factors.
Suchita, Joshi, Sailesh, Kotecha
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Human lung growth starts as a primitive lung bud in early embryonic life and undergoes several morphological stages which continue into postnatal life. Each stage of lung growth is a result of complex and tightly regulated events governed by physical, environmental, hormonal and genetic factors.
Suchita, Joshi, Sailesh, Kotecha
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Rhinovirus and the developing lung
Paediatric Respiratory Reviews, 2014Human rhinovirus (HRV) infections are now widely accepted as the commonest cause of acute respiratory illnesses (ARIs) in children. Advanced PCR techniques have enabled HRV infections to be identified as causative agents in most common ARIs in childhood including bronchiolitis, acute asthma, pneumonia and croup.
D W, Cox, P N, Le Souëf
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MicroRNAs and lung development
Pediatric Pulmonology, 2012AbstractMicroRNAs (miRNAs) constitute a large group of small (∼22 nucleotides), non‐coding RNA sequences that are highly conserved among animals, plants and microorganisms, suggesting that microRNAs represent a highly conserved and important regulatory mechanism. They have been demonstrated to play an important role in gene regulation. Recently, miRNAs
Naghmeh, Khoshgoo +3 more
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Growth and development of the lung
The Journal of Pediatrics, 1981THE STUDY of growth and development of the lung provides insights into the pathogenesis and sequelae of congenital malformations and is important in understanding how lung growth is altered by disease and by environmental factors. This review focuses on the clinical implications of normal, abnormal, and compensatory lung growth and development from a ...
L S, Inselman, R B, Mellins
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THE DEVELOPMENT OF THE LUNGS OF LAMBS
Pediatrics, 19651. Lambs with estimated gestational ages from 55 to 154 days were delivered by cesarean section. Observations were made on animals in the fetal state and after the onset of respiration in lambs of more than 130 days gestation. Spontaneously born lambs were also studied. 2.
M M, ORZALESI +5 more
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Lung Disease and Brain Development
Neonatology, 2006With the technical progress made in fetal and neonatal intensive care, perinatal mortality has decreased by 25% over the last decade and has expanded the surviving premature population. Prematurity drastically changes the environment of the developing organism.
Hüppi, Petra Susan +2 more
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Prematurity and the Developing Lung
Clinics in Perinatology, 1992Bronchopulmonary dysplasia results from treatment of immature lungs resulting from an abnormally short gestation or from pulmonary hypoplasia. Lung hypoplasia secondary to lung compression, oligohydramnios, or diminished complexity of tissue. Normal lung development and the pathologic process associated with lung hypoplasia and their effects of ...
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Birth Defects Research Part C: Embryo Today: Reviews, 2008
AbstractNicotine is found in tobacco smoke. It is a habit forming substance and is prescribed by health professionals to assist smokers to quit smoking. It is rapidly absorbed from the lungs of smokers. It crosses the placenta and accumulates in the developing fetus.
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AbstractNicotine is found in tobacco smoke. It is a habit forming substance and is prescribed by health professionals to assist smokers to quit smoking. It is rapidly absorbed from the lungs of smokers. It crosses the placenta and accumulates in the developing fetus.
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