Results 111 to 120 of about 7,388,180 (256)

Pulmonary artery pressure in chronic obstructive pulmonary disease without resting hypoxaemia

, 2011
BACKGROUND: Chronic obstructive pulmonary disease (COPD) can lead to pulmonary hypertension and cor pulmonale, which are predictors of mortality. OBJECTIVE: To identify predictors of increased pulmonary artery pressure (PAP) in COPD patients without ...
Y. K. Lee, T-H. Kim, Kim, WJ, Seo, JB, Lee, JH, Lim, SY, Lee, SY, J-H. Lee, J. H. Lee, Shin, TR, Oh, YM, W. J. Kim, S. Y. Lee, Yoon, HI, Y-M. Oh, Kim, TH, Lee, YK, E-K. Kim, Lee, SD, Huh, JW, T. R. Shin, S-D. Lee, Lee, SM, S. Y. Lim, S-M. Lee, Sheen, SS, J. B. Seo, S. S. Sheen, H. I. Yoon, J. S. Lee, J. W. Huh, Kim, EK, Lee, JS, 이진화   +33 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Building peer information exchange networks to improve child and adolescent TB care in Sub-Saharan Africa

Public Health Action
The Sub-Saharan Africa Regional Child and Adolescent TB Centre of Excellence (COE) was established in 2019 to address gaps in child and adolescent TB care in the region.
R. Mande, S.D. Berger, B. Moore, P. Thekkur, J.P. Dongo, J. Doyle, J. Harris, S.M. Graham, R.A. Dlodlo   +8 more
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

Evolving Concepts in Progressive Pulmonary Fibrosis: A Clinical Update

Journal of Respiration
Progressive pulmonary fibrosis (PPF) is a clinical syndrome associated with worsening quality of life and increased mortality among patients with various interstitial lung diseases.
María Belén Noboa-Sevilla, Fernanda Hernández-González, Sandra Cuerpo-Cardeñosa, Xavier Alsina-Restoy, Nancy Pérez-Rodas, Alejandro Frino-García, Miguel Alonso-Villares, Elvis Matheus-Ramírez, Jacobo Sellarés   +8 more
doaj   +1 more source

Vascular normalization confers an endothelial immune suppressive gene expression profile

Molecular Oncology, EarlyView.
We compare the immunoregulatory gene expression profiles of healthy endothelial cells or endothelial cells from tumors having a normalized endothelium (low leakage) with that of wild‐type tumors (high leakage) and observe that the wild‐type tumor endothelium exhibits immunostimulatory properties.
Liqun He, Michael Welsh
wiley   +1 more source

Nontuberculous mycobacterial lung disease

, 2015
NTM stands for nontuberculous mycobacteria. NTMs are a group of bacteria in the same family as the organism that causes tuberculosis (TB). Over 140 NTMs have been identified, though only 20-30 have been linked to human disease.

core  

Interleukin-6 and airflow limitation in chemical warfare patients with chronic obstructive pulmonary disease [PDF]

Objectives: Chronic obstructive pulmonary disease (COPD) is one of the main late complications of sulfur mustard poisoning. The aim of this study was to evaluate serum levels of interleukin (IL)-6 in war veterans with pulmonary complications of sulfur ...
خواجه دلوئی, محمد, Shahrzad Lari, توحیدی, محمد, آیت اللهی, حسین, محمدزاده لاری, شهرزاد, قبادی مراللو, حسن, عطاران, داود, بصیری, رضا, قانعی, مصطفی   +8 more
core   +1 more source