Results 151 to 160 of about 1,346,074 (337)

Critical evaluation of the Global DOTS Expansion Plan

Bulletin of the World Health Organization, 2007
The development of the DOTS Expansion Plan has been a milestone in tuberculosis (TB) control at the global and national levels. Key challenges that remain are overcoming the weakness of a strategy built on case management, sustaining commitment ...
Donald A Enarson, Nils E Billo
doaj  

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Lung Disease Due to Inhaled Dusts [PDF]

, 1959
K. M. A. Perry
openalex   +1 more source

Hepatic ABCG5/G8 overexpression reduces apoB-lipoproteins and atherosclerosis when cholesterol absorption is inhibited

Journal of Lipid Research, 2007
We previously reported that liver-specific overexpression of ABCG5/G8 in mice is not atheroprotective, suggesting that increased biliary cholesterol secretion must be coupled with decreased intestinal cholesterol absorption to increase net sterol loss ...
Federica Basso, Lita A. Freeman, Carol Ko, Charles Joyce, Marcelo J. Amar, Robert D. Shamburek, Terese Tansey, Fairwell Thomas, Justina Wu, Beverly Paigen, Alan T. Remaley, Silvia Santamarina-Fojo, H. Bryan Brewer, Jr.   +12 more
doaj  

Automated diagnosis of lung diseases using vision transformer: a comparative study on chest x-ray classification [PDF]

arXiv
Background: Lung disease is a significant health issue, particularly in children and elderly individuals. It often results from lung infections and is one of the leading causes of mortality in children. Globally, lung-related diseases claim many lives each year, making early and accurate diagnoses crucial.
arxiv  

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

A Case of Diseased Testicle, Accompanied withDisease of the Lungs and Brain, and Terminating Fatally [PDF]

Henry Earle
openalex   +1 more source

Hydatid Disease of Spleen and Left Lung [PDF]

, 1880
Wm. S. Paget
openalex   +1 more source

FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production

FEBS Open Bio, EarlyView.
FAM136A depletion upregulated ROS production, reduced mitochondrial membrane potential (ΔΨ) and ATP production, and upregulated expression of PCK1, PCK2, HMGCS1, and HMGCS2. The expression of both TOMM22 and TOMM20 was also upregulated. FAM136A depletion reduced HCCS that produce holocytochrome c by combining heme to apocytochrome c, and reduced the ...
Yushi Otsuka, Masato Yano
wiley   +1 more source