Results 81 to 90 of about 2,421,996 (355)

Comparison of the triglyceride lipase of liver, adipose tissue, and postheparin plasma

Journal of Lipid Research, 1972
Heparin-released triglyceride lipase from three sources, adipose tissue, liver, and postheparin plasma, was compared. Heparin-released triglyceride lipase from liver differed in several major respects from that in adipose tissue.
John C. LaRosa, Robert I. Levy, Herbert G. Windmueller, Donald S. Fredrickson   +3 more
doaj   +1 more source

Single cell RNA sequencing reveals distinct clusters of Irf8-expressing pulmonary conventional dendritic cells

Frontiers in Immunology, 2023
A single population of interferon-regulatory factor 8 (Irf8)-dependent conventional dendritic cell (cDC type1) is considered to be responsible for both immunogenic and tolerogenic responses depending on the surrounding cytokine milieu. Here, we challenge
Adan Chari Jirmo, Adan Chari Jirmo, Ruth Grychtol, Ruth Grychtol, Svenja Gaedcke, Bin Liu, Stephanie DeStefano, Christine Happle, Christine Happle, Olga Halle, Olga Halle, Joao T. Monteiro, Joao T. Monteiro, Anika Habener, Anika Habener, Oliver D. Breiholz, David DeLuca, Gesine Hansen, Gesine Hansen, Gesine Hansen   +19 more
doaj   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Fungal lung disease [PDF]

European Respiratory Journal
Fungal lung disease encompasses a wide spectrum of organisms and associated clinical conditions, presenting a significant global health challenge. The type and severity of disease are determined by underlying host immunity and infecting fungal strain.
Tavleen Kaur Jaggi, Ritesh Agarwal, Pei Yee Tiew, Anand Shah, Emily C. Lydon, Chadi A. Hage, Grant W. Waterer, Charles R. Langelier, Laurence Delhaes, Sanjay H. Chotirmall   +9 more
openaire   +3 more sources

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

Molecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo, Carlos M. Martínez‐Cáceres, Manuel Bernabé‐García, Vicente Munitiz, David Ruiz de Angulo, Pascual Parrilla, Ángeles Ortiz, Luisa F. Martínez de Haro, María L. Cayuela   +8 more
wiley   +1 more source

Does the Structured Operational Research and Training Initiative (SORT IT) continue to influence health policy and/or practice?

Global Health Action, 2018
Background: The Structured Operational Research and Training Initiative (SORT IT) is a successful model of integrated operational research and capacity building with about 90% of participants completing the training and publishing in scientific journals.
Jaya Prasad Tripathy, Ajay MV Kumar, Nathalie Guillerm, Selma Dar Berger, Karen Bissell, Anthony Reid, Rony Zachariah, Andrew Ramsay, Anthony D Harries   +8 more
doaj   +1 more source

The two-stage clonal expansion model in occupational cancer epidemiology: Results from three cohort studies [PDF]

, 2010
Copyright © 2010 by the BMJ Publishing Group Ltd. All rights reserved.Objectives: The objective of this work was to apply the two-stage clonal expansion model, with the intention to expand the literature on epidemiological applications of the model and ...
Gore, R, Kriebel, D, Zeka, A
core   +1 more source

Interstitial lung disease [PDF]

European Respiratory Review, 2013
This article reviews the most important articles published in interstitial lung disease, as reviewed during the Clinical Year in Review session at the 2012 annual European Respiratory Society Congress in Vienna, Austria.Since the recent international guidelines for the management of idiopathic pulmonary fibrosis (IPF), important new evidence is ...
openaire   +4 more sources

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Bushfire smoke is pro-inflammatory and suppresses macrophage phagocytic function

Scientific Reports, 2018
Bushfires are increasing in frequency and severity worldwide. Bushfire smoke contains organic/inorganic compounds including aldehydes and acrolein. We described suppressive effects of tobacco smoke on the phagocytic capacity of airway macrophages, linked
Rhys Hamon, Hai B. Tran, Eugene Roscioli, Miranda Ween, Hubertus Jersmann, Sandra Hodge   +5 more
doaj   +1 more source