Results 131 to 140 of about 271,261 (306)

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Pathogenic SMAD6 variants in patients with idiopathic and complex congenital heart disease associated pulmonary arterial hypertension

npj Genomic Medicine
In patients with complex congenital heart disease (CHD) pathogenic SMAD6 variants have been described previously. The aim of this study was to analyze if pathogenic SMAD6 variants also occur in patients with CHD associated with pulmonary arterial ...
Sofia Karl, Ekkehard Grünig, Memoona Shaukat, Matthias Held, Christian Apitz, Fabian von Scheidt, Ralf Geiger, Michael Halank, Karen M. Olsson, Marius M. Hoeper, Jan C. Kamp, Gabor Kovacs, Horst Olschewski, Hans-Jürgen Seyfarth, Katrin Milger, Ralf Ewert, Hans Klose, Benjamin Egenlauf, Panagiota Xanthouli, Katrin Hinderhofer, Christina A. Eichstaedt   +20 more
doaj   +1 more source

Cell Calcification Models and Their Implications for Medicine and Biomaterial Research

Advanced Healthcare Materials, EarlyView.
Calcification, is the process by which the tissues containing minerals are formed, occurring during normal physiological processes, or in pathological conditions. Here, it is aimed to give a comprehensive overview of the range of cell models available, and the approaches taken by these models, highlighting when and how methodological divergences arise,
Luke Hunter, Caterina Vanelli Coralli, Robert Dzhanaev, Aaron Morgan, Willi Jahnen‐Dechent, Sergio Bertazzo   +5 more
wiley   +1 more source

Optimization of the Nonclinical Biological Evaluation of Medical Devices Using Toxicologic Pathology Best Practices

Advanced Healthcare Materials, EarlyView.
Nonclinical evaluation of biological responses to implanted medical devices and combination products in animals is required to predict possible outcomes and risks in patients. This paper describes globally accepted pathology “best practices” that 1) effectively address ISO standards and current regulatory guidance for medical device development and 2 ...
Kathleen A. Funk, JoAnn C. L. Schuh, Brad Bolon, Valerie S. Thomas, Jeffrey I. Everitt, Abraham Nyska, Jaime Paulin   +6 more
wiley   +1 more source

Overcoming reduced glucocorticoid sensitivity in airway disease:molecular mechanisms and therapeutic approaches [PDF]

, 2010
Abraham, Adcock, Ali, Allfrey, Auphan, Barnes, Barnes, Barnes, Barnes, Bartholome, Bartling, Bartling, Bateman, Beesley, Bergeron, Bhavsar, Bhavsar, Bourbeau, Cai, Calverley, Carmichael, Carrabino, Charmandari, Chen, Cho, Chung, Chung, Chung, Ciencewicki, Condliffe, Cosio, Cosio, Culpitt, Culpitt, Denslow, Duma, Evans, Ferreira, Fitzpatrick, Freedman, Gagliardo, Galasinski, Galliher-Beckley, Galliher-Beckley, Goleva, Gross, Gross, Hakonarson, Haller, Hew, Hogg, Hwang, Ian M. Adcock, Irusen, Ito, Ito, Ito, Ito, Ito, Ito, Jatakanon, John, John A. Marwick, Karp, Keatings, Kian Fan Chung, King, Kino, Kitagawa, Kleiman, Knoepfler, Konstan, Korn, Kovacs, Krstic, Kumar, Kumar, Kurashima, Laffargue, Langhoff, Lee, Lee, Lewis-Tuffin, Li, Li, Liu, Lu, Macedo, Mak, Mannino, Marone, Marwick, Marwick, Marwick, Marwick, Marwick, Matysiak, Meagher, Medicherla, Meja, Miller, Molnarfi, Moore, Murphy, Muselet-Charlier, Onda, Osoata, OʼSullivan, Pace, Patel, Pratt, Pujols, Pujols, Rahman, Rahman, Raia, Reichardt, Renda, Rennard, Rhen, Rogatsky, Rommel, Rottner, Rumora, Saccani, Sadhu, Sasaki, Schacke, Scheinman, Schermer, Sethi, Silverstein, Smith, Smolonska, Stav, Strickland, Suissa, Szatmuíry, Thomson, Tomlinson, Tuckermann, Tudhope, Ukena, Usmani, van Rensen, Verhaeghe, Ward, Ward, Wood, Wright, Young   +150 more
core   +1 more source

Decellularized Extracellular Matrix Scaffolds to Engineer the Dormant Landscape of Microscopic Colorectal Cancer Liver Metastasis

Advanced Healthcare Materials, EarlyView.
Decellularized liver extracellular matrix scaffolds provide a platform to study dormant liver‐metastatic colorectal cancer. They induce reversible dormancy, in combination with nutrient depletion and low dose chemotherapy, through cell cycle arrest and chemotherapy resistance.
Sabrina N. VandenHeuvel, Lucia L. Nash, Abigail J. Clevenger, Claudia A. Collier, Oscar R. Benavides, Sanjana Roy, Brinlee Goggans, Aelita Salikhova, Anvitha Tharakesh, Svasti Haricharan, Amber N. Stratman, Scott Kopetz, Alex J. Walsh, Shreya A. Raghavan   +13 more
wiley   +1 more source

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening

Advanced Healthcare Materials, EarlyView.
Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Ayumi Suzuki, Yuji Nashimoto, Hirokazu Kaji, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida, Kensuke Miyake, Yutaro Mori   +20 more
wiley   +1 more source

Bioprinting Organs—Science or Fiction?—A Review From Students to Students

Advanced Healthcare Materials, EarlyView.
Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu, Camilla Mussoni, Mateo S. Andrade Mier, Paula Buettner, Nathaly Chicaiza‐Cabezas, Yi‐Yu Robin Dai, Jessica Faber, Maren Fiedler, Zan Lamberger, Xuen Jen Ng, Vanessa Moessler, Anna Rederer, Jonas Roeder, Sabrina Stecher, Katinka Theis, Jeanette Weigelt, Silvia Budday, Gregor Lang, Natascha Schaefer   +18 more
wiley   +1 more source

Extracellular‐Matrix‐Based Materials from Decellularized Tissue: Opportunities, Challenges, and Future Directions in Regenerative Medicine

Advanced Healthcare Materials, EarlyView.
Extracellular matrix‐based materials derived from decellularized tissue (dECM) harness the tissue's native bioactivity to guide repair and regeneration across diverse clinical applications. This perspective highlights clinical uses of dECM biomaterials and advances in fabrication methods such as electrospinning and 3D printing.
Madeline Laude, Vasiliki Kolliopoulos, Antonios G. Mikos, Lisa J. White, Elizabeth Cosgriff‐Hernandez   +4 more
wiley   +1 more source