Results 151 to 160 of about 801,766 (352)

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

ERS statement on standardisation of cardiopulmonary exercise testing in chronic lung diseases [PDF]

, 2019
The objective of this document was to standardise published cardiopulmonary exercise testing (CPET) protocols for improved interpretation in clinical settings and multicentre research projects.
Aguilaniu, Armstrong, Asterios Kampouras, Beaver, Bell, Borg, Boyce, Campbell, Causer, Chris Burtin, Clark, Corra, Cranston, Crisafulli, Daniel Langer, Danilo Berton, Dillard, Dimitris Kontopidis, Dionne C.W. Braeken, Don S. Urquhart, Ernst Eber, Evans, Farley, Frits M.E. Franssen, Georgios Kaltsakas, Gift, Grant, Grenvik, Groepenhoff, Hartman, Hebestreit, Hebestreit, Helge Hebestreit, Holm, Huszczuk, Ioannis Vogiatzis, J. Alberto Neder, Jana De Brandt, Jeanette Boyd, Johns, Johnson, Johnson, Jones, Kor, Krahenbuhl, Loe, Martijn A. Spruit, McArdle, Miller, Milo A. Puhan, Miyamura, Myers, Nagle, Naughton, Ochmann, Orenstein, Palange, Peveler, Pierantonio Laveneziana, Porszasz, Richard Casaburi, Riddell, Ries, Roberto A. Rabinovich, Roman, Saey, Samuel Verges, Sarah Crook, Sauwaluk Dacha, Schaun, Sheehan, Siler, Stickland, Thierry Troosters, Thomas Radtke, Thomy Tonia, Wagner, Ward, Wasserman, Wasserman, Whipp, Williams, Wilmore, Yeh, Yoshiya, Yvonne M.J. Goërtz, Zafeiris Louvaris, Zeballos, Zhang   +88 more
core   +3 more sources

Living Microalgae‐Based Magnetic Microrobots for Calcium Overload and Photodynamic Synergetic Cancer Therapy

Advanced Healthcare Materials, EarlyView.
A magnetic microrobot fabricated by Spirulina platensis is proposed to accumulate in tumor regions and generate in situ high calcium concentration and sufficient oxygen. These characteristics of the microrobot present a strategy for triggering calcium overload therapy and chlorophyll‐mediated photodynamic therapy, and such combination resulted in a ...
Shuai Jiang, Bo Hao, Xin Song, Yihang Jiang, Junjia Guo, Yuqiong Wang, Qinglong Wang, Xin Wang, Tiantian Xu, Xinyu Wu, Kai Fung Chan, Philip Wai Yan Chiu, Li Zhang   +12 more
wiley   +1 more source

The importance of Alpha-1 Antitrypsin (AAT) and respiratory rehabilitation in patients with lung diseases [PDF]

Balneo and PRM Research Journal
Background: The incidence of lung diseases is very high worldwide, especially in the case of lung cancer, pulmonary tuberculosis, and obstructive ventilatory dysfunctions.
Gabriela-Marina Andrei (Brînduș), Mihai Olteanu, Eugenia-Andreea Marcu , Maria Bălășoiu, Elena-Camelia Piciu, Ramona Cioboată, Magdalena Rodica Trăistaru   +6 more
doaj   +1 more source

Global initiative for chronic obstructive lung diseases (GOLD): time to act

European Respiratory Journal, 2001
In January 1997, chronic obstructive pulmonary disease (COPD) experts from several countries met in Brussels, Belgium to explore the development of a Global Initiative for Chronic Obstructive Lung Disease (GOLD).
R. Pauwels
semanticscholar   +1 more source

Ovarian Function Restoration with Biomimetic Scaffold Incorporating Angiogenic Molecules and Antioxidant in Chemotherapy‐Induced Perimenopausal Model

Advanced Healthcare Materials, EarlyView.
This study developed a biomimetic scaffold incorporating PDRN and melatonin to restore ovarian function in chemotherapy‐induced premature ovarian insufficiency, enhancing cell survival, folliculogenesis, and hormone normalization, while improving fertility rates and offspring in a mouse model, offering a promising strategy for ovarian function ...
Da‐Seul Kim, Dong Seok Jeong, So‐Yeon Park, Ji‐Won Jung, Jeoung Eun Lee, Jun‐Kyu Lee, Seung‐Woon Baek, Dong Ryul Lee, Dong Keun Han   +8 more
wiley   +1 more source

Human CFTR deficient iPSC-macrophages reveal impaired functional and transcriptomic response upon Pseudomonas aeruginosa infection

Frontiers in Immunology
IntroductionCystic fibrosis (CF) is a hereditary autosomal recessive disease driven by deleterious variants of the CFTR gene, leading, among other symptoms, to increased lung infection susceptibility.
Claudio Rodriguez Gonzalez, Débora Basílio-Queirós, Anna-Lena Neehus, Anna-Lena Neehus, Anna-Lena Neehus, Anna-Lena Neehus, Anna-Lena Neehus, Sylvia Merkert, Sylvia Merkert, Sylvia Merkert, David Tschritter, Sinem Ünal, Sinem Ünal, Jan Hegermann, Jan Hegermann, Matthias Mörgelin, Jacinta Bustamante, Jacinta Bustamante, Jacinta Bustamante, Jacinta Bustamante, Manuel Manfred Nietert, Ulrich Martin, Ulrich Martin, Ulrich Martin, Burkhard Tümmler, Burkhard Tümmler, Antje Munder, Antje Munder, Nico Lachmann, Nico Lachmann, Nico Lachmann, Nico Lachmann, Nico Lachmann   +32 more
doaj   +1 more source

Ischemic Myocardium Targeting Peptide‐Guided Nanobubbles for Multimodal Imaging and Treatment of Coronary Microvascular Dysfunction

Advanced Healthcare Materials, EarlyView.
Nanobubbles functionalized with indocyanine green and ischemic myocardium‐targeting peptide effectively target cardiomyocytes and enable the multimodal (fluorescence, ultrasonic, and photoacoustic) imaging of ischemic myocardium in mice with coronary microvascular dysfunction (CMD).
Bo Yu, Ziwei Pang, Jing Zhao, Jingyi Xue, Hsuan Lo, Tiancheng Gu, Ping Zhang, Jiawei Tian, Guo‐Qing Du   +8 more
wiley   +1 more source

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Pathogenic SMAD6 variants in patients with idiopathic and complex congenital heart disease associated pulmonary arterial hypertension

npj Genomic Medicine
In patients with complex congenital heart disease (CHD) pathogenic SMAD6 variants have been described previously. The aim of this study was to analyze if pathogenic SMAD6 variants also occur in patients with CHD associated with pulmonary arterial ...
Sofia Karl, Ekkehard Grünig, Memoona Shaukat, Matthias Held, Christian Apitz, Fabian von Scheidt, Ralf Geiger, Michael Halank, Karen M. Olsson, Marius M. Hoeper, Jan C. Kamp, Gabor Kovacs, Horst Olschewski, Hans-Jürgen Seyfarth, Katrin Milger, Ralf Ewert, Hans Klose, Benjamin Egenlauf, Panagiota Xanthouli, Katrin Hinderhofer, Christina A. Eichstaedt   +20 more
doaj   +1 more source