Results 31 to 40 of about 28,971 (207)

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Pyogenic lung abscess in an infectious disease unit: a 20-year retrospective study

Therapeutic Advances in Respiratory Disease, 2021
Background: Pyogenic lung abscesses are rare and poorly described infections. This study aimed to describe their prognostic factors. Methods: We retrospectively included all patients hospitalized between 1 January 1998 and 1 June 2018, with an ...
Thomas Maitre, Vichita Ok, Ruxandra Calin, Ludovic Lassel, Ana Canestri, Michel Denis, Mohammed Hamidi, Sebastian Tavolaro, Charlotte Verdet, Antoine Parrot, Jacques Cadranel, Gilles Pialoux   +11 more
doaj   +1 more source

Amodiaquine Enhances Anti‐Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils

Advanced Science, EarlyView.
This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong, Chunyuan Zhao, Chengxi Li, Lin Weng, Zehan Ji, Peiqi Li, Jiqiang Lu, Danni Liu, Anni Yu, Tianyi Jiang, Shaokai Huang, Heng Liu, Xiao Chen, Zichun Hua   +13 more
wiley   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Forma pseudoneoplásica de esquistossomose pulmonar crônica sem hipertensão pulmonar Pseudotumoral presentation of chronic pulmonary schistosomiasis without pulmonary hypertension

Jornal Brasileiro de Pneumologia, 2009
A esquistossomose é uma doença que, no Brasil, é causada pelo Schistosoma mansoni e transmitida através da água por moluscos do gênero Biomphalaria. Essa espécie ocorre na África, nas Antilhas e na América do Sul.
Gisane Cavalcanti Rodrigues, Domício Carvalho Lacerda, Edson da Silva Gusmão, Fernando Antônio Colares, Vinícius Turano Mota   +4 more
doaj   +1 more source

Wild Boars (Sus scrofa, L. 1758) from Castile and Leon Region (Spain): A Histopathology Survey

Animals, 2022
Wild boars are wild ungulates with a wide distribution in Europe, with a relevant role in wildlife and public health. In Spain, high (and sometimes artificial) densities of wild boars are responsible for several health problems.
Catarina Jota Baptista, José M. Gonzalo-Orden, Luís J. Merino-Goyenechea, Paula A. Oliveira, Fernanda Seixas   +4 more
doaj   +1 more source

Rapidly progressive respiratory failure after helminth larvae ingestion

BMC Pulmonary Medicine, 2021
Background Self-administration of helminths has gained attention among patients as a potential but unproven therapy for autoimmune disease. We present a case of rapidly progressive respiratory failure in a patient with systemic sclerosis (SSc) and ...
Anahit A. Zeynalyan, Balaji Kolasani, Chetan Naik, Christopher J. G. Sigakis, Leann Silhan, Susan K. Mathai   +5 more
doaj   +1 more source

An Investigation of Hyperostosis Frontalis Interna in a Modern Anatomical Body Donor Population

Clinical Anatomy, EarlyView.
ABSTRACT This research sought to examine the prevalence and severity of hyperostosis frontalis interna (HFI) in the Chicagoland anatomical body donor population. The study further aimed to elucidate potential demographic risk factors for HFI, including sex, age at death, and structural vulnerability index (SVI), as well as any common comorbidities, as ...
Amy C. Beresheim, Amanda Hall
wiley   +1 more source

Infection Risk From Humans and Animals in the Anatomy Laboratory: A Scoping Review

Clinical Anatomy, EarlyView.
ABSTRACT Whole‐body dissection is a cornerstone of anatomy education. During and following the COVID‐19 pandemic, exposure to infectious agents and other risks of dissection were highlighted. To identify potential risks, one must have the data outlining these risks in specific situations.
Margaret A. McNulty, Elizabeth R. Agosto
wiley   +1 more source

First report of Crenosoma vulpis in Africa and Eucoleus aerophilus in Algeria

International Journal for Parasitology: Parasites and Wildlife, 2023
Introduction: Crenosoma vulpis and Eucoleus aerophilus are widely distributed lungworms infecting carnivores, mainly red foxes, and are localized in the trachea, bronchi and bronchioles.
Noureddine Mechouk, Georgiana Deak, Angela Monica Ionică, Corina Gina Toma, Zihad Bouslama, Andrei Daniel Mihalca   +5 more
doaj   +1 more source