Results 231 to 240 of about 1,947,503 (351)

Effects of Roflumilast on Exacerbations and Lung Function in COPD Patients with Bronchiectasis. [PDF]

Chonnam Med J
Lee JK, Yoon CS, Kho BG, Kim TO, Shin HJ, Kwon YS, Kim YI, Lim SC.   +7 more
europepmc   +1 more source

Changes in Lung Function and Fractional Exhaled Nitric Oxide Across Wildfire Seasons in the Wildland Firefighter Exposure and Health Effect (Wffehe) Study

Chieh-Ming Wu, Kathleen A. Clark, Olorunfemi Adetona, Kathleen Navarro DuBose, Corey Butler, Alejandra Ramirez‐Cardenas, James B. Odei, Molly R. West, Christa Hale   +8 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Role of the <i>ADAM33</i> rs2280091 Variant in Modulating Lung Function in Cystic Fibrosis. [PDF]

Int J Mol Sci
Dos Santos VS, Mello LS, Marques LFA, Silva LR, Bertuzzo CS, Ribeiro JD, Marson FAL.   +6 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Lung development genes, adult lung function and cardiovascular comorbidities. [PDF]

Thorax
Portas L, Talaei M, Dean C, Aung N, Hind MD, Pozarickij A, Walters RG, China Kadoorie Biobank Collaborative Group, Burney PG, Petersen S, Minelli C, Shaheen SO.   +11 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Associations of interstitial lung disease subtype and CT pattern with lung function and survival. [PDF]

Thorax
Kim JS, Pugashetti J, Ma SF, Huang Y, Podolanczuk AJ, Lynch DA, Oh A, Mychaleckyj J, Manichaikul A, Rich S, Chua F, Adams TM, Flaherty KR, Lee JS, Lasky JA, Raghu G, Murray S, Spino C, Martinez FJ, Noth I, Humphries SM, Adegunsoye A, Molyneaux PL, Oldham JM, Newton CA.   +24 more
europepmc   +1 more source

Faculty Opinions recommendation of Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.

, 2017
Erik Melén
openalex   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source