Results 81 to 90 of about 981,607 (293)

WDR72 Promotes Neuroblastoma Stemness and Progression by Sequestering TRIM31‐Mediated Degradation of CBX8

open access: yesAdvanced Science, EarlyView.
This study unveiled that METTL14 mediates m6A modification of WDR72 mRNA to stabilize and enhance WDR72 expression, which disrupts TRIM31‐mediated ubiquitination of CBX8 protein and retards its degradation, finally the elevated CBX8 contributes to tumor stemness.
Huijuan Zeng   +13 more
wiley   +1 more source

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

open access: yesAdvanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen   +8 more
wiley   +1 more source

Classification of Chest CT Lung Nodules Using Collaborative Deep Learning Model [PDF]

open access: yes
Khalaf Alshamrani,1,2 Hassan A Alshamrani1 1Radiological Sciences Department, Najran University, Najran, Saudi Arabia; 2Department of Oncology and Metabolism, University of Sheffield, Sheffield, UKCorrespondence: Khalaf Alshamrani, Department of Oncology
Alshamrani HA, Alshamrani K
core  

When A Lung Nodule is not the Usual Lung Nodule: the Rare Entity of PEComa

open access: yesJournal of Respiratory Research, 2018
n ...
Flavio Colaut   +2 more
openaire   +3 more sources

A Review of Image Segmentation Methods for Lung Nodule Detection Based on Computed Tomography Images

open access: yesMATEC Web of Conferences, 2018
The detection and segmentation of lung nodules based on computer tomography images (CT) is a basic and significant step to achieve the robotic needle biopsy.
Zheng Li, Lei Yiran
doaj   +1 more source

ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

open access: yesAdvanced Science, EarlyView.
ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu   +10 more
wiley   +1 more source

A Programmable Calcification Nanoplatform for Loco‐Regional Calcification‐Immune Hepatocellular Carcinoma Therapy

open access: yesAdvanced Science, EarlyView.
An in situ‐grown BP‐CaO2 nanoplatform supplies coordinated Ca2+, endogenous phosphate, and oxidative stress to convert tumor calcification from a passive endpoint into an active immune‐remodeling process. Widespread hydroxyapatite deposition is visualized by CT, while multi‐omics reveals MCOLN2 as a calcium‐responsive mediator linking biomineralization
Long Liu   +11 more
wiley   +1 more source

Volumetric measurements of lung nodules with multi-detector row CT: Effect of changes in lung volume [PDF]

open access: yes, 2006
OBJECTIVE: To evaluate how changes in lung volume affect volumetric measurements of lung nodules using a multi-detector row CT. MATERIALS AND METHODS: Ten subjects with asthma or chronic bronchitis who had one or more lung nodules were included. For each
Goo, Jin Mo   +6 more
core   +1 more source

Comparison of lung cancer occurring in fibrotic versus non-fibrotic lung on chest CT

open access: yesJournal of Translational Medicine
Purpose Evaluate the behavior of lung nodules occurring in areas of pulmonary fibrosis and compare them to pulmonary nodules occurring in the non-fibrotic lung parenchyma. Methods This retrospective review of chest CT scans and electronic medical records
Mary M. Salvatore   +7 more
doaj   +1 more source

Computed tomography-guided biopsy of small lung nodules: diagnostic accuracy and analysis for true negatives

open access: yesJournal of International Medical Research, 2020
Objective We evaluated the diagnostic accuracy of computed tomography (CT)-guided transthoracic core needle biopsy (TCNB) for small (≤20-mm) lung nodules and identified predictive factors for true negatives among benign biopsy results. Methods From March
Xing-Li Liu   +6 more
doaj   +1 more source

Home - About - Disclaimer - Privacy