Results 191 to 200 of about 131,647 (261)

Combined Heart-Lung Transplant for Pulmonary Artery Aneurysm Secondary to Pulmonary Arterial Hypertension. [PDF]

JACC Case Rep
Kerai AP, Killian AC, Hoopes CW, Orozco-Hernandez E.   +3 more
europepmc   +1 more source

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

Ventilation heterogeneity early post lung transplant as a marker of future bronchiolitis obliterans syndrome and mortality - A 10 year study. [PDF]

JHLT Open
Thompson BR, Ellis MJ, Matsas P, Verbanck S, Snell GI.   +4 more
europepmc   +1 more source

Interleukin‐39 is a Prognostic Biomarker and Therapy Target for Sepsis

Advanced Science, EarlyView.
Sepsis triggers a significant increase in IL‐39 production, with circulating levels markedly elevated and positively correlated with disease severity and poor clinical prognosis in sepsis patients. Mechanistically, macrophage‐derived IL‐39 activates the GP130 signaling pathway via a ligand‐receptor interaction, thereby fueling the pro‐inflammatory ...
Feng‐zhi Zhang, Hai‐jun Liu, Yan Yue, Jun‐jie Gao, Jin Zhang, Wen‐wu Zhang, Yun‐long Zhang, Wei‐hua Lu, Sheng‐wei Jin, Pu‐hong Zhang   +9 more
wiley   +1 more source

Sex Differences in Muscle-Respiratory Function Relationship in Lung Transplant Patients: A Longitudinal Study. [PDF]

J Cachexia Sarcopenia Muscle
Ceolin C, Alessi A, Citron A, Loy M, Papa MV, Andaloro C, Zanforlini BM, Devita M, Bertolino S, Gonnelli S, Seccia DM, Bertocco A, Rea F, Sergi G, De Rui M.   +14 more
europepmc   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

%dd-cfDNA: The New Frontier for Heart/Lung Transplant Surveillance? [PDF]

Transpl Int
Agbor-Enoh S, Fraser E, Nadella N, Andargie TE, Alnababteh M.   +4 more
europepmc   +1 more source

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

Lung transplantation in a patient with a true tracheal bronchusCentral Message

JTCVS Techniques
Mahmoud Y. Hashim, MD, Turki Salem, MD, Marcello Migliore, MD, PhD, Khaled Al-Kattan, MD, PhD, Waleed Saleh, MD   +4 more
doaj   +1 more source

ABO-incompatible pediatric lung transplant performed with immunoadsorption column system: A case report. [PDF]

JTCVS Open
Fontana Bellorín A, Vázquez Sánchez A, Monfort Drago V, Issitt R, Álvarez P, Jordá Aragón C, Sales Badía G.   +6 more
europepmc   +1 more source