Results 231 to 240 of about 273,336 (352)

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

open access: yesAdvanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen   +11 more
wiley   +1 more source

Coronavirus and Chronic Lung Allograft Dysfunction: Hiding in Plain Sight?

open access: yesTransplantation Direct, 2018
Alicia B. Mitchell, BMedSc(Hons)   +1 more
doaj   +1 more source

Everolimus-Induced Pulmonary Toxicity in a Lung Transplant Recipient: A Case Report. [PDF]

open access: yesCureus
Varón-Vega F   +5 more
europepmc   +1 more source

Attenuated Bacteria‐Based Tumor Therapy: Clinical Application Risks, Marketing Approval Restrictions, and Coping Strategies

open access: yesAdvanced Science, EarlyView.
This review comprehensively overviews attenuated bacteria‐based tumor therapy, highlighting key methodologies and recent progress. It examines strategies for enhancing safety, stabilizing efficacy, optimizing manufacturing, and navigating regulatory pathways.
Yucheng Liu   +8 more
wiley   +1 more source

Lung Ischemia-Reperfusion Injury in Lung Transplant Surgery: Where Do We Stand? [PDF]

open access: yesAntioxidants (Basel)
Berzenji L   +11 more
europepmc   +1 more source

PHENOTYPIC T-CELL CHANGES IN THORACIC TRANSPLANT RECIPIENTS IMMUNOSUPPRESSED WITH FK506 [PDF]

open access: yes, 1991
ARMITAGE, J   +9 more
core  

Phocaeicola coprophilus‐Derived 6‐Methyluracil Attenuates Radiation‐Induced Intestinal Fibrosis by Suppressing the IDO1‐Kynurenine‐AHR Axis

open access: yesAdvanced Science, EarlyView.
IR‐induced dysbiosis depletes P. coprophilus and its metabolite 6‐methyluracil, leading to disinhibition of the IDO1‐Kyn‐AHR axis. This results in sustained fibroblast activation and collagen deposition, driving radiation induced intestinal fibrosis. ABSTRACT Therapeutic options for radiation‐induced intestinal fibrosis (RIF) remain limited. This study
Jiaxin Zhang   +11 more
wiley   +1 more source

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