Results 151 to 160 of about 374,691 (355)

Paracorporeal Artificial Lung Circuit as a Possibility for Bridge to Lung Transplantation [PDF]

, 2009
Thomas Puehler, Alois Philipp, Çhristof Schmid   +2 more
openalex   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

Single Cell and Spatial Transcriptomics Define a Proinflammatory and Profibrotic Niche After Kidney Injury

Advanced Science, EarlyView.
By integrating single‐cell RNA sequencing and spatial transcriptomics, tenascin C (TNC) is unveiled as a central organizer of the proinflammatory and profibrotic niche in kidney fibrosis. TNC promotes macrophage activation through TLR4/NF‐κB signaling, leading to renal inflammation and fibrosis.
Li Li, Jinlin Liao, Yuxi Zhang, Zifu Yao, Junxin Huang, Kejia Wu, Lu Li, Yiling Peng, Haili Zhu, Xue Hong, Xi Liu, Lili Zhou, Fan Fan Hou, Haiyan Fu, Youhua Liu   +14 more
wiley   +1 more source

Identification of immune signatures associated with both SARS-CoV-2 infection and lung transplantation [PDF]

Andrew D. Hoffmann, Hannah F. Almubarak, Radhika Iyer, Sam E Weinberg, Joshua R Squires, Chengsheng Mao, Juncheng Wei, Shuvam Chaudhuri, Lamiaa El-Shennawy, Nurmaa K. Dashzeveg, Yuzhi Jia, Alexis R. Demonbreun, Matthew J. Schipma, Yuan Luo, Suchitra Swaminathan, Michael G. Ison, Huiping Liu, Deyu Fang   +17 more
openalex   +1 more source

First Report of Daratumumab in Clinical Lung Transplantation

, 2022
Péter Jaksch, G. Muraközy, G. Fischer, H. Konrad, Alberto Benazzo   +4 more
openalex   +1 more source

Tissue‐Resident Macrophage‐Derived E3 Ligase SMURF2 Restricts Autoimmune Inflammation by Mediating the Degradation of p‐TBK1

Advanced Science, EarlyView.
Dysregulated Tissue resident macrophage (TRMs) link to autoimmune inflammation. SMURF2 mediates Lys‐27 (K27)‐linked ubiquitination of p‐TBK1 and its degradation, which inhibits CSF1R signaling‐triggered TRM proliferation, thereby restraining the autoimmune inflammation.
Xiang An, Jun Li, Lingling Wang, Chengyuan Li, Zhenpeng Jin, Yushi Yao, Minmin Jiang, Wenlong Lin, Xiaojian Wang   +8 more
wiley   +1 more source

Length of “naked” residual esophagus and correlation with the occurrence of cervical anastomotic leakage after esophagectomy

JTCVS Open, 2022
Guoqing Zhang, MD, Hang Yang, MD, Xiangnan Li, MD, PhD, Jindong Li, MD, PhD   +3 more
doaj   +1 more source

Quadruple-drug induction therapy in highly sensitized patients [PDF]

, 1988
Abendroth, D., Illner, Wolf-Dieter, Land, Walter, Schleibner, S.   +3 more
core   +1 more source

tRNA‐Derived Fragment tRF‐22 Promotes Immunosuppression by Inhibiting HnRNPAB Ubiquitination in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
tRF‐22 fosters an immunosuppressive and pro‐oncogenic tumor microenvironment in ESCC by stabilizing hnRNPAB against TRIM25‐mediated ubiquitination and enhancing TGFβ2 expression, which increases PMN‐MDSCs infiltration and suppresses CD8+ T cells. Targeting tRF‐22 or blocking TGFβ signalling improves anti‐PD1 response, offering a promising therapeutic ...
Ling Pan, Xin Qin, Li Gong, Haining Liu, Bo Cheng, Jing Wang, Yajie Hu, Lingxing Zeng, Yiping Wang, Qingxu Song, Yufeng Cheng   +10 more
wiley   +1 more source

Recent improvement in clinical pancreas transplantation [PDF]

, 1987
Abendroth, D., Illner, Wolf-Dieter, Land, Walter, Landgraf, R., Schleibner, S.   +4 more
core   +1 more source