Results 151 to 160 of about 164,398 (291)

Immunological Similarities and Differences between Post-COVID-19 Lung Sequelae and Idiopathic Pulmonary Fibrosis

Biomedicines
Introduction: Pulmonary fibrosis is an irreversible condition that may be caused by known (including viral triggers such as SARS-CoV-2) and unknown insults.
Sara Gangi, Laura Bergantini, Paolo Cameli, Irene Paggi, Marco Spalletti, Fabrizio Mezzasalma, Elena Bargagli, Miriana d’Alessandro   +7 more
doaj   +1 more source

Lung Transplantation in a Patient with Fibrosing Alveolitis [PDF]

, 1971
P. Hugh‐Jones, A. M. Macarthur, P. A. Cullum, Susan A. Mason, W. A. Crosbie, D HUTCHISON, M. C. Winterton, A P Smith, Brooke Mason, L. A. Smith   +9 more
openalex   +1 more source

CK2B Induces CD8+ T‐Cell Exhaustion through HDAC8‐Mediated Epigenetic Reprogramming to Limit the Efficacy of Anti‐PD‐1 Therapy in Non‐Small‐Cell Lung Cancer

Advanced Science, EarlyView.
αPD‐1 therapy has left an indelible mark in the field of NSCLC treatment; however, its efficacy is limited in clinical practice owing to the effector T‐cell exhaustion. These findings underscore CK2B as a promising target for overcoming the exhaustion of effector CD8+ T cells, thereby enhancing the efficacy of αPD‐1 and adoptive cell therapies in NSCLC.
Shaochuan Liu, Shiya Ma, Gen Liu, Lingjie Hou, Yong Guan, Liang Liu, Yuan Meng, Wenwen Yu, Ting Liu, Li Zhou, Zhiyong Yuan, Shuju Pang, Siyuan Zhang, Junyi Li, Xiubao Ren, Qian Sun   +15 more
wiley   +1 more source

Synthetic Lethality of SHP2 and XIAP Suppresses Proliferation and Metastasis in KRAS‐mutant Nonsmall Cell Lung Cancer

Advanced Science, EarlyView.
Embelin cotargets SHP2 to disrupt the SHP2/GRB2/SOS complex, inhibiting cancer‐related signaling pathways such as MAPK, (PI3K)/AKT pathway, and XIAP to induce apoptosis signaling pathway, respectively, leading to synthetic lethality in KRAS‐mutant NSCLC cells both in vivo and in vitro.
Nai‐jie Fu, Yu‐wen Sheng, Zhe Fan, Zhao Wu, Ling‐yu Li, Rui‐ying Xi, Xiao‐ke Shi, Guo‐lin Zhang, Fei Wang   +8 more
wiley   +1 more source

ROS‐Activated Nanohydrogel Scaffolds with Multi‐Factors Controlled Release for Targeted Dual‐Lineage Repair of Osteochondral Defects

Advanced Science, EarlyView.
ROS‐activated nanohydrogels composite bilayer scaffolds are rationally designed for targted dual‐lineage repair of osteochondral defects. The as‐prepared nanohydrogel scaffolds provided 3D culture and induced dual‐lineage differentiation of BMSCs in vitro, efficiently inhibited early‐stage inflammation by rapidly releasing DS and improved cartilage and
Xiuhui Wang, Shunli Wu, Ruiyang Li, Huijian Yang, Yue Sun, Zijie Cao, Xiao Chen, Yan Hu, Hao Zhang, Zhen Geng, Long Bai, Zhongmin Shi, Ke Xu, Hongbo Tan, Jiacan Su   +14 more
wiley   +1 more source

Diaphragm and Lung Transplantation

Transplant International
Mutual interactions between the diaphragm and lung transplantation (LTx) are known to exist. Before LTx, many factors can exert notable impact on the diaphragmatic function, such as the underlying respiratory disease, the comorbidities, and the chronic treatments of the patient.
Alessandro Palleschi, Alessandro Palleschi, Giovanni Mattioni, Giovanni Mattioni, Antonella LoMauro, Emilia Privitera, Valeria Musso, Letizia Morlacchi, Letizia Morlacchi, Maurizio Vergari, Daniele Velardo, Giacomo Grasselli, Giacomo Grasselli   +12 more
openaire   +4 more sources

Lactylation‐Driven HECTD2 Limits the Response of Hepatocellular Carcinoma to Lenvatinib

Advanced Science, EarlyView.
HECTD2 serves as an E3 ubiquitin ligase of KEAP1 to facilitate the antioxidative response and contributes to lenvatinib resistance in hepatocellular carcinoma. Lactylation of histone 3 on lysine residue 18 drives HECTD2 transcription. Targeting HECTD2 using PLGA‐PEG‐based nanoparticles offers novel strategies to overcome lenvatinib resistance in ...
Runyu Dong, Yao Fei, Yiren He, Peng Gao, Bo Zhang, Menglin Zhu, Zhixiong Wang, Longfei Wu, Shuai Wu, Xiaoming Wang, Juan Cai, Zhiqiang Chen, Xueliang Zuo   +12 more
wiley   +1 more source

CpG‐Based Nanovaccines Enhance Ovarian Cancer Immune Response by Gbp2‐Mediated Remodeling of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CpG‐based nanovaccines bolster ovarian cancer immunotherapy via the Gbp2‐Pin1‐NFkB pathway‐mediated reprogramming of tumor‐associated macrophages (TAMs.) Moreover, this nanovaccine can alleviate chemotherapy‐induced immunosuppression by augmenting the proportion of M1‐like TAMs, enhancing the infiltration of CD8+ T cells, and downregulating the ...
Jiaqiang Xiong, Juyuan Huang, Hanxiao Xu, Qiuji Wu, Jiahui Zhao, Yurou Chen, Guanlan Fan, Haotong Guan, Rourou Xiao, Zhaojin He, Siqi Wu, Wenliang Ouyang, Shixuan Wang, Lu Zhang, Peng Xia, Wei Zhang, Meng Wu   +16 more
wiley   +1 more source

Pathological findings following lung transplantation. [PDF]

, 1972
Κ.B. Shilkin, Lynne Reid
openalex   +1 more source

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Advanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang   +5 more
wiley   +1 more source