Results 181 to 190 of about 164,398 (291)

Biomimetic MOF Nanocarrier‐Mediated Synergistic Delivery of Mitochondria and Anti‐Inflammatory miRNA to Alleviate Acute Lung Injury

Advanced Science, EarlyView.
A biomimetic MOF nanocarrier for macrophage‐targeting delivery of both mitochondria and anti‐miR‐127 is designed with an aim to revitalize macrophages and remold the inflammatory microenvironment for treating acute lung injury. By leveraging the macrophages‐targeting property and pH‐responsiveness, ZIF‐8 nanocarriers facilitated efficient delivery of ...
Xin Shou, Changjiang Chen, Hangjie Ying, Zhiyun Liu, Lingyao Zeng, Qiujie Li, Lanjie Lei, Bingyong Mao, Wei Zhang, Shumao Cui, Liyun Shi   +10 more
wiley   +1 more source

Identification of pyroptosis‐related gene prognostic signature in head and neck squamous cell carcinoma

Cancer Medicine, Volume 11, Issue 24, Page 5129-5144, December 2022., 2022
We built and verified a risk model for HNSCC prognosis using 7 pyroptosis‐related signature genes, which could facilitate the implementation of the HNSCC treatment. Abstract Background Head and neck squamous cell carcinoma (HNSCC) is a life‐threatening disease with poor prognosis.
Zhanzhan Li, Lin Shen, Yanyan Li, Liangfang Shen, Na Li   +4 more
wiley   +1 more source

EXTRAHEPATIC FACTOR VIII SYNTHESIS LUNG TRANSPLANTS IN HEMOPHILIC DOGS

, 1974
J.J. Veltkamp, E. ASFAOU, K. VAN DE TORREN, J. A. Van der Does, Nico H. van Tilburg, E. K. J. Pauwels   +5 more
openalex   +1 more source

Plac1+ Tumor Cell‐Treg Interplay Supports Tumorigenesis and Progression of Head and Neck Cancer

Advanced Science, EarlyView.
Meng et al. screen genes in the CTAs family and find Plac1 is specifically expressed in head and neck squamous cell carcinoma (HNSCC) cells. They reveal that Plac1 expression promotes HNSCC progression directly by activating PI3K/AKT signaling pathway.
Xiaoyan Meng, Zhonglong Liu, Lu Zhao, Ran Li, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +8 more
wiley   +1 more source

Antifungal Compounds from the Leaves of Rhynchosia minima

Chemistry &Biodiversity, Volume 19, Issue 12, December 2022., 2022
Abstract Rhynchosia minima, commonly known as jumby bean, is used as a remedy for respiratory ailments in various parts of the world. It is also used by South African traditional healers to treat heart or chest pain. This study aimed to investigate the bioactive constituents of the leaf extracts of R.
Adetola H. Adewole, Ibukun M. Famuyide, Lyndy J. McGaw, Mamoalosi A. Selepe, Natasha October   +4 more
wiley   +1 more source

KK2DP7 Stimulates CD11b+ Cell Populations in the Spleen to Elicit Trained Immunity for Anti‐Tumor Therapy

Advanced Science, EarlyView.
This study introduces KK2DP7, a dendrimer‐structured peptide adjuvant, as a tool to decode trained immunity's role in antitumor therapy. Splenic CD11b+ cells mediate tumor suppression via TLR2‐IRF7 activation and epigenetic reprogramming, validated by adoptive transfer experiments.
Rui Zhang, Lin Tang, Yusi Wang, Xuejing Zhou, Zhenyu Ding, Li Yang   +5 more
wiley   +1 more source

Epipolythiodioxopiperazine‐Based Natural Products: Building Blocks, Biosynthesis and Biological Activities

ChemBioChem, Volume 23, Issue 23, December 5, 2022., 2022
Housing sulfur: Certain fungi produce diketopiperazine compounds with a transannular sulfur bridge. These so‐called epipolythiodioxopiperzines are toxic by non‐specifically interacting with intracellular proteins and contribute to fungal pathogenicity. Producer strains serve as bio‐pesticides but also question safety of food fermentation.
Eva M. Huber
wiley   +1 more source

Long-Term Survival in the Immediately Functioning Transplanted Primate Lung: Physiological Findings

, 1971
William L. Joseph, Donald L. Morton
openalex   +1 more source

Identification of CD38high Monocyte as a Candidate Diagnostic Biomarker and Therapeutic Target for Sepsis

Advanced Science, EarlyView.
This study uncovers that CD38high monocytes discriminate sepsis and sterile inflammation and are associated with 28‐day mortality in bacterial sepsis. Targeting CD38 therapy reduces inflammatory response in monocytes and in sepsis mice model. Mechanistically, CD38‐HIF‐1α/glycolysis/MGO loop exacerbates sepsis‐induced immune dysregulation.
Ning Hua, Limin Kong, Li Fan, Yanan Bai, Yujun Zhou, Yanfang Zhang, Qingwei Zhao, Xiaoyang Lu, Hongyu Yang, Hangyang Li, Peili Ding, Yuyu Nan, Qinghua Ji, Ping Yang, Lu Li, Yijing Xin, Lijuan Zhao, Wei Yang, Wenqiao Yu, Saiping Jiang   +19 more
wiley   +1 more source

PROLONGED SURVIVAL OF LUNG ALLOGRAFTS IN NONIDENTICAL BEAGLES BY TREATMENT WITH LETHAL TOTAL-BODY IRRADIATION, AUTOLOGOUS BONE MARROW TRANSPLANTATION, AND METHOTREXATE

, 1978
NULL AUTHOR_ID
openalex   +1 more source