Results 181 to 190 of about 1,460,646 (299)

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source

Aberrant and ectopic cell populations in restrictive allograft syndrome after lung transplantation. [PDF]

Eur Respir J
Leiber LM, Christian L, Neubert L, Ruwisch J, Yilmaz H, Schwarz EKJ, Langer LT, Kamp JC, Greer M, Haermeyer B, Kühnel M, Werlein C, Justet A, Bergmann AK, Beeckmans H, Ballmaier M, Salman J, Vos R, Knudsen L, Martin U, Vanaudenaerde BM, Yildirim AÖ, Hohlfeld JM, Ius F, Laenger F, Welte T, Falk C, Kaminski N, Jonigk DD, Gottlieb J, Schupp JC.   +30 more
europepmc   +1 more source

Checkpoint‐Directed Glycoengineering Reprograms the Vascular Lumen for Siglec‐Mediated Immune Regulation

Advanced Science, EarlyView.
Checkpoint‐directed glycoengineering installs sialylated ligands on the donor vascular lumen during ex vivo preservation, creating a localized Siglec‐7/9‐engaging interface. The engineered glycocalyx suppresses immune‐cell activation, complement deposition, and microvascular injury in arterial and kidney allografts while preserving endothelial ...
Md Mohosin Rana, Javairia F. Rahim, Aaron P. Bernstein, Peyman Malek Mohammadi Nouri, Lyann Sim, Winnie Enns, Jenice M. Dumlao, Haiming D. Luo, Irina Chafeeva, Hong‐Ming Chen, Aizhou Wang, Jiao‐Jing Wang, Edward N. Schmidt, Zheng Jenny Zhang, Marcelo Cypel, Christopher Nguan, Matthew S. Macauley, Stephen G. Withers, Jonathan C. Choy, Jayachandran N. Kizhakkedathu   +19 more
wiley   +1 more source

Single versus double lung transplantation in patients with pneumoconiosis: a retrospective cohort study. [PDF]

J Occup Med Toxicol
Chen C, Huang Y, Li Z, Wu J, Zhong W, Chen L, Liu F, Qiao G.   +7 more
europepmc   +1 more source

Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation

Advanced Science, EarlyView.
Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir, Yagmur Ozendi, Gokhan Burcin Kubat, Keshav K. Singh   +3 more
wiley   +1 more source

Functional, Volumetric, and Growth Outcomes After Pediatric Bilateral Lung Transplantation. [PDF]

Pediatr Transplant
Bae SY, Park S, Kim DH, Yun T, Park JH, Na B, Na KJ, Lee HJ, Park JS, Suh DI, Park J, Park IK, Kang CH, Kim YT.   +13 more
europepmc   +1 more source

Tumor‐Intrinsic HEXB Drives Endothelial‐To‐Mesenchymal Transition and Confers Resistance to Anti‐Angiogenic Therapy in Glioblastoma

Advanced Science, EarlyView.
This study elucidates how glioblastoma tumors develop resistance to anti‐VEGF therapy through endothelial‐to‐mesenchymal transition (Endo‐MT). The researchers identify a novel signaling pathway where tumor‐derived HEXB stabilizes HSP60 to drive this vascular reprogramming.
Tianqi Liu, Xin Chen, Tao Sun, Jianqi Wu, Haixu Yan, Xing Liu, Hongda Lin, Xiangyu Wang, Ziao Xiao, Yang Xu, Qiang Fu, Peng Cheng, Wen Cheng, Anhua Wu   +13 more
wiley   +1 more source

Patient-Reported Quality of Life in Lung Transplantation: Prospective Cohort Study. [PDF]

Interact J Med Res
Li P, Wang J, Wang H, Li S, Wang L, Gao S, Hu C, Zhang G.   +7 more
europepmc   +1 more source

Ultrasound‐Triggered piRNA Delivery Using Biomimetic Phase‐Changeable Nanoparticles for Theranostics of Myocardial Infarction

Advanced Science, EarlyView.
A biomimetic ultrasound‐responsive piRNA delivery nanoparticle platform (piR‐NPs) enables targeted delivery and ultrasound (US)‐triggered release of piR‐1873 in infarcted myocardium. The released piR‐1873 suppresses Usp2‐mediated RIP1/RIP3/MLKL necroptosis, reduces myocardial injury and fibrosis, and promotes cardiac functional recovery, providing a ...
Yajun Zhang, Hongzhao Qi, Yanyan Yang, Feng Wang, Tiantian Han, Yanbei Lei, Xiaolu Li, Zhibin Wang, Hua Qu, Tao Yu, Pin Sun   +10 more
wiley   +1 more source

Is Lifelong Physical Activity a Determinant of Lung Transplantation Outcomes? [PDF]

J Clin Med
Muklewicz N, Gallas M, Żegleń BS, Grzegorczyk KB, Żołnowska M, Góra AK, Lipka K, Chmura K, Gradek A, Nojek R, Piotrowska M, Sawczuk M, Szydzik F, Tarnowska JA, Wojarski J, Karolak W, Żegleń S.   +16 more
europepmc   +1 more source